Status of chromosome breaks and gaps in breast cancer: a follow-up study

Genetic susceptibility and environmental factors are believed to be responsible for chromosomal instabilities and higher incidence of breast cancer. We conducted a follow-up study to find the levels of chromosome breaks and gaps in 20 premenopausal women with breast cancer before surgery, 1 month af...

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Bibliographic Details
Published in:Cancer genetics and cytogenetics 2001-10, Vol.130 (2), p.155-159
Main Authors: Ray, G.N, Shahid, M, Husain, S.A
Format: Article
Language:English
Subjects:
Adult
Age Factors
Biological and medical sciences
Breast Neoplasms - diagnosis
Breast Neoplasms - genetics
Case-Control Studies
Chromosome Aberrations
Female
Follow-Up Studies
Gynecology. Andrology. Obstetrics
Humans
Mammary gland diseases
Medical sciences
Middle Aged
Premenopause
Risk Factors
Time Factors
Tumors
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Summary:Genetic susceptibility and environmental factors are believed to be responsible for chromosomal instabilities and higher incidence of breast cancer. We conducted a follow-up study to find the levels of chromosome breaks and gaps in 20 premenopausal women with breast cancer before surgery, 1 month after surgery, and 3 years after surgery with respect to 20 age- and gender-matched controls. The mean level of chromosome breaks and gaps was found to be significantly higher ( P
ISSN:0165-4608
1873-4456
DOI:10.1016/S0165-4608(01)00482-4