Genetic male infertility and medically assisted reproduction

About half the cases of infertility have their origin in the male partner. Infertility due to males has several possible aetiologies. In about 30% of cases, genetic disorders are suspected of being the main cause. They could interfere with the development of the male gonads, the urogenital tract or...

Full description

Saved in:
Bibliographic Details
Published in:Gynécologie, obstétrique & fertilité obstétrique & fertilité, 2001-09, Vol.29 (9), p.583
Main Authors: May-Panloup, P, Malinge, M C, Larget-Piet, L, Chrétien, M F
Format: Article
Language:fre
Subjects:
Chromosome Aberrations
Cystic Fibrosis Transmembrane Conductance Regulator - genetics
Female
Genetic Counseling
Humans
Infertility, Male - genetics
Infertility, Male - therapy
Karyotyping
Male
Mutation
Pregnancy
Pregnancy, Multiple
Reproductive Techniques, Assisted
Sex Chromosome Aberrations
Spermatogenesis - genetics
Y Chromosome
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:About half the cases of infertility have their origin in the male partner. Infertility due to males has several possible aetiologies. In about 30% of cases, genetic disorders are suspected of being the main cause. They could interfere with the development of the male gonads, the urogenital tract or the hypothalamo-hypophyseal axes. Such disorders could also stop germ cell generation and maturation or lead to the production of non-functional spermatozoa. Genetic disorders of chromosomal origin could give rise to abnormal karyotypes or germinal mosic figure. They could involve gene abnormalities affecting numerous genes localized on several chromosomes, in particular the Y chromosome. The physiopathologic identification of male infertility is interesting because of the risk of the genetic factors involved being transmitted to the offspring. The subject is of importance, specially because of the increasing use of intracytoplasmic sperm injections. Couples should therefore be precisely counselled to enable them to make a well-informed choice among various solutions, e.g. ART, with or without sperm donation, or adoption.
ISSN:1297-9589