The Estrogen Trinity: Membrane, Cytosolic, and Nuclear Effects

Angel Nadal 1 , Mario Díaz 2 and Miguel A. Valverde 3 1 Institut de Bioenginyeria, Universitat Miguel Hernández, Campus de Sant Joan, 03550 Alacant; 2 Laboratorio de Fisiologia Animal, Departamento de Biologia Animal, Universidad de La Laguna, 38206 Tenerife; and 3 Unitat de Senyalització Cellular,...

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Bibliographic Details
Published in:News in physiological sciences 2001-12, Vol.16 (6), p.251-255
Main Authors: Nadal, Angel, Diaz, Mario, Valverde, Miguel A
Format: Article
Language:English
Subjects:
Animals
Cell Membrane - physiology
Cell Nucleus - physiology
Cytosol - physiology
Estrogen Receptor alpha
Estrogens - physiology
Receptors, Estrogen - physiology
Receptors, Neurotransmitter - metabolism
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Summary:Angel Nadal 1 , Mario Díaz 2 and Miguel A. Valverde 3 1 Institut de Bioenginyeria, Universitat Miguel Hernández, Campus de Sant Joan, 03550 Alacant; 2 Laboratorio de Fisiologia Animal, Departamento de Biologia Animal, Universidad de La Laguna, 38206 Tenerife; and 3 Unitat de Senyalització Cellular, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, C/Dr. Aiguader 80, 08003 Barcelona, Spain Estrogens have a wide array of biological effects, targeting both genomic and nongenomic mechanisms. Classically, the estrogen receptors activating the transcription machinery in the nucleus were thought to be distinct from the extranuclear estrogen receptors. Recently, this conceptual wall has started to be dismantled as the result of the identification of novel routes of estrogen action.
ISSN:1548-9213
0886-1714
1548-9221
DOI:10.1152/physiologyonline.2001.16.6.251