Transesophageal and transthoracic echocardiography and Doppler-examinations in systemic lupus erythematosus

Objective : To search for cardiac abnormalities in systemic lupus erythematosus (SLE). Methods : 35 patients examined by 2-D transthoracal Doppler and transesophageal echocardiography. Results : Mitral and aortic valve abnormalities were seen in 12 patients (34%) respectively, and occurred altogethe...

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Bibliographic Details
Published in:Scandinavian journal of rheumatology 2001, Vol.30 (5), p.275-281
Main Author: Omdal, Per Lunde, Knut Rasmussen, Svein Ivar Mellgren, Gunnar Husby, Roald
Format: Article
Language:English
Subjects:
Adrenal Cortex Hormones - adverse effects
Adrenal Cortex Hormones - therapeutic use
Adult
Aged
Aortic Valve - abnormalities
Aortic Valve - diagnostic imaging
Biological and medical sciences
Calcinosis - etiology
Cardiovascular system
Echocardiography, Doppler
Esophagus - diagnostic imaging
Female
Fibrosis
Heart Diseases - diagnostic imaging
Heart Diseases - etiology
Humans
Investigative techniques, diagnostic techniques (general aspects)
Lupus Erythematosus, Systemic - complications
Lupus Erythematosus, Systemic - diagnostic imaging
Male
Medical sciences
Middle Aged
Mitral Valve - abnormalities
Mitral Valve - diagnostic imaging
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Systemic Lupus Erythematosus Heart Disease Echocardiography
Ultrasonic investigative techniques
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Summary:Objective : To search for cardiac abnormalities in systemic lupus erythematosus (SLE). Methods : 35 patients examined by 2-D transthoracal Doppler and transesophageal echocardiography. Results : Mitral and aortic valve abnormalities were seen in 12 patients (34%) respectively, and occurred altogether in 16 patients (46%). They were in general significantly associated with longer disease duration, but not with anticardiolipin antibodies (aCL), disease activity, or any other variable, except for time on corticosteroids, which was significantly longer in patients with aortic valve calcifications. Conclusion : Valve masses and valve thickening - often in combination - are the most frequent structural findings in SLE, occurring more often on the aortic than on the mitral valves. Factors other than antiphospholipid antibodies, medication, hypertension, or coronary heart disease seem to be responsible for this phenomenon. Drugs that modulate inflammation in endo- and pericardial tissue may, at least in part, be responsible for the observed mitral valve calcifications and pericardial fibrosis.
ISSN:0300-9742
1502-7732
DOI:10.1080/030097401753180354