Relation of Serum 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) Level to Hematological Examination Results in Veterans of Operation Ranch Hand

The authors studied indices of hematologic function and exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in Vietnam War veterans of Operation Ranch Hand-the Air Force unit responsible for the aerial spraying of Agent Orange and other herbicides in Vietnam. The herbicides were contaminated with...

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Bibliographic Details
Published in:Archives of environmental health 2001-09, Vol.56 (5), p.396-405
Main Authors: Michalek, Joel E., Akhtar, Fatema Z., Longnecker, Matthew P., Burton, Joseph E.
Format: Article
Language:English
Subjects:
2,4,5-Trichlorophenoxyacetic Acid - adverse effects
2,4,5-Trichlorophenoxyacetic Acid - chemistry
2,4-Dichlorophenoxyacetic Acid - adverse effects
2,4-Dichlorophenoxyacetic Acid - chemistry
Agent Orange
Biological and medical sciences
Chemical and industrial products toxicology. Toxic occupational diseases
Defoliants, Chemical - adverse effects
Defoliants, Chemical - chemistry
dioxin
Environmental Pollutants - adverse effects
Environmental Pollutants - blood
Erythrocyte Indices - drug effects
Half-Life
hematology
Humans
Male
Medical sciences
Middle Aged
Occupational Exposure
Platelet Count
Polychlorinated Dibenzodioxins - adverse effects
Polychlorinated Dibenzodioxins - blood
Polychlorinated Dibenzodioxins - chemistry
Prospective Studies
TCDD
Toxicology
Various organic compounds
Veterans
Vietnam
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Summary:The authors studied indices of hematologic function and exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in Vietnam War veterans of Operation Ranch Hand-the Air Force unit responsible for the aerial spraying of Agent Orange and other herbicides in Vietnam. The herbicides were contaminated with TCDD. The authors measured TCDD serum levels in 1987 or later and extrapolated the result to the time of service in Vietnam. The authors studied serum TCDD level in relation to red blood cell count, hemoglobin, hematocrit, mean corpuscular volume, white blood cell count, platelet count, and erythrocyte sedimentation rate at each of 4 physical examinations. Compared with veterans not involved in Operation Ranch Hand, those with the highest TCDD levels in Operation Ranch Hand had mean corpuscular volumes that were about 1 % higher and platelet counts that were about 4% higher. These small increases were unlikely to be of clinical significance and may not have been caused by TCDD.
ISSN:0003-9896
2331-4303
DOI:10.1080/00039890109604474