INHIBITORY EFFECT OF IMMUNOGLOBULIN E PRODUCTION BY JIN-DEUK-CHAL (SIEGESBECKIA ORIENTALIS)

Elevated levels of immunoglobulin (Ig) E are associated with immediate-type allergic reactions. Jin-deuk-chal is the whole plant of Siegesbeckia orientalis (SO) sL. Immunization of mice with small amounts of protein antigens on alum results in several fold increases in total plasma IgE, much of it s...

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Published in:Immunopharmacology and immunotoxicology 2001-01, Vol.23 (4), p.555-563
Main Authors: Hwang, Woo-Jun, Park, Eun-Jeung, Jang, Chul-Ho, Han, Seung-Woo, Oh, Gyung-Jae, Kim, Nam-Song, Kim, Hyung-Min
Format: Article
Language:English
Subjects:
Animals
Asteraceae
B Cells
B-Lymphocytes - drug effects
B-Lymphocytes - immunology
Biological and medical sciences
Enzyme-Linked Immunosorbent Assay
Female
General pharmacology
Humans
IgE
IL-4
Immunoglobulin E - biosynthesis
Interleukin-4 - immunology
Lipopolysaccharides - pharmacology
Medical sciences
Mice
Mice, Inbred ICR
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Extracts - pharmacology
Siegesbeckia orientalis
Spleen - drug effects
Spleen - immunology
Tumor Cells, Cultured
U266B1
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Summary:Elevated levels of immunoglobulin (Ig) E are associated with immediate-type allergic reactions. Jin-deuk-chal is the whole plant of Siegesbeckia orientalis (SO) sL. Immunization of mice with small amounts of protein antigens on alum results in several fold increases in total plasma IgE, much of it specific for the immunizing antigen. In the present study, we investigated the effect of Siegesbeckia orientalis (SO) on IgE production. SO inhibited the plasma levels of IgE induced by antigens. The effects of SO on the interleukin (IL)-4-dependent IgE response by mouse whole spleen cells were studied. IL-4 dependent IgE production of lipopolysaccharide (LPS)-stimulated whole spleen cells was inhibited by SO. In addition, using U266B1 human IgE-bearing B cells, we found that SO inhibited the production of IgE activated by LPS plus IL-4. These results suggest that SO have antiallergic activity by inhibition of IgE production from B cells.
ISSN:0892-3973
1532-2513
DOI:10.1081/IPH-100108601