Achyrofuran, a New Antihyperglycemic Dibenzofuran from the South American Medicinal Plant Achyrocline satureioides

A new prenylated dibenzofuran, achyrofuran (2), was isolated from an extract of Achyrocline satureioides by bioassay-guided fractionation using the db/db mouse model for type 2 diabetes. Compound 2significantly lowered blood glucose levels in this model when administered orally at 20 mg/kg q.d.

Saved in:
Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2002-02, Vol.65 (2), p.203-205
Main Authors: CARNEY, John R., KRENISKY, Joann M., WILLIAMSON, R. Thomas, LUO, Jian
Format: Article
Language:English
Subjects:
Animals
Asteraceae - chemistry
Biological and medical sciences
Chromatography, Thin Layer
Diabetes Mellitus, Type 2 - chemically induced
Diabetes Mellitus, Type 2 - drug therapy
Furans - chemistry
Furans - isolation & purification
Furans - pharmacology
General pharmacology
Hypoglycemic Agents - chemistry
Hypoglycemic Agents - isolation & purification
Hypoglycemic Agents - pharmacology
Mass Spectrometry
Medical sciences
Mice
Mice, Inbred Strains
Models, Animal
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Peru
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plants, Medicinal - chemistry
Pyrones - chemistry
Pyrones - isolation & purification
Pyrones - pharmacology
Spectrophotometry, Ultraviolet
Structure-Activity Relationship
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A new prenylated dibenzofuran, achyrofuran (2), was isolated from an extract of Achyrocline satureioides by bioassay-guided fractionation using the db/db mouse model for type 2 diabetes. Compound 2significantly lowered blood glucose levels in this model when administered orally at 20 mg/kg q.d.
ISSN:0163-3864
1520-6025
DOI:10.1021/np010374l