Benzoylphloroglucinol derivatives from Hypericum scabrum

Nine new polyprenylated benzoylphloroglucinol derivatives, hyperibones A-I (1-9), were isolated from the aerial parts of the Uzbekistan medicinal plant Hypericum scabrum. Their structures were determined mainly on the basis of spectroscopic evidence (2D NMR and HRMS). Compounds 1, 2, and 4 showed mi...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2002-03, Vol.65 (3), p.290
Main Authors: Matsuhisa, Michiko, Shikishima, Yasuhiro, Takaishi, Yoshihisa, Honda, Gisho, Ito, Michiho, Takeda, Yoshio, Shibata, Hirohumi, Higuti, Tomihiko, Kodzhimatov, Olimjon K, Ashurmetov, Ozodbek
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Chromatography, High Pressure Liquid
Drug Resistance, Microbial
Hypericum - chemistry
Methicillin Resistance - physiology
Microbial Sensitivity Tests
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Phloroglucinol - analogs & derivatives
Phloroglucinol - chemistry
Phloroglucinol - isolation & purification
Phloroglucinol - pharmacology
Plants, Medicinal - chemistry
Spectroscopy, Fourier Transform Infrared
Staphylococcus aureus - drug effects
Uzbekistan
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Summary:Nine new polyprenylated benzoylphloroglucinol derivatives, hyperibones A-I (1-9), were isolated from the aerial parts of the Uzbekistan medicinal plant Hypericum scabrum. Their structures were determined mainly on the basis of spectroscopic evidence (2D NMR and HRMS). Compounds 1, 2, and 4 showed mild in vitro antibacterial activity against methicillin-resistance Staphylococus aureus (MRSA) and methicillin-sensitive Staphylococus aureus (MSSA).
ISSN:0163-3864
DOI:10.1021/np010310a