Pharmacological properties of the methanol extract from Mentha suaveolens Ehrh

The present study analyses the pharmacological activity in in vivo and in vitro models of the methanol extract obtained from the leaves and steams of Menta suaveolens Ehrh. This extract lacked toxicity, but exhibited a central nervous system depressant action; an analgesic effect in models of chemic...

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Bibliographic Details
Published in:Phytotherapy research 2002-03, Vol.16 (S1), p.10-13
Main Authors: Moreno, Lucrecia, Bello, Regina, Primo-Yúfera, Eduardo, Esplugues, Juan
Format: Article
Language:English
Subjects:
analgesia
Analgesics - administration & dosage
Analgesics - pharmacology
Analgesics - therapeutic use
Animals
Anti-Inflammatory Agents, Non-Steroidal - administration & dosage
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
antiinflammatory effect
Biological and medical sciences
Carrageenan
Edema - chemically induced
Edema - prevention & control
effects on CNS
Female
General pharmacology
in vitro
Medical sciences
Mentha
Mentha suaveolens
Mice
Pain - prevention & control
Pain Measurement - drug effects
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phytotherapy
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Plant Leaves
plants extracts
Rats
Rats, Wistar
smooth muscle
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Summary:The present study analyses the pharmacological activity in in vivo and in vitro models of the methanol extract obtained from the leaves and steams of Menta suaveolens Ehrh. This extract lacked toxicity, but exhibited a central nervous system depressant action; an analgesic effect in models of chemical and mechanical stimulation suggesting the induction of a peripheral analgesic response. The extract also exhibited an antiinflammatory action inhibiting the rat paw oedema induced by carrageenin. Moreover, the in vitro studies showed a significant diminution in the contractile effects induced by histamine, serotonin and acetylcholine. Copyright © 2002 John Wiley & Sons, Ltd.
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.744