Apoptosis, proliferation and p12(doc-1) profiles in normal, dysplastic and malignant squamous epithelium of the Syrian hamster cheek pouch model

Disruption of the homeostatic balance between proliferation and apoptosis is widely believed to contribute to human oral carcinogenesis. Using the Syrian hamster oral cancer model, we examined normal, hyperplastic, dysplastic and malignant oral epithelium for the fraction of apoptotic, proliferating...

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Bibliographic Details
Published in:Oral oncology 2002-04, Vol.38 (3), p.274
Main Authors: Kohno, Yohko, Patel, Vipul, Kim, Yong, Tsuji, Takanori, Chin, Byung Rho, Sun, Moyi, Bruce Donoff, R, Kent, Ralph, Wong, David, Todd, Randy
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - pathology
Cheek
Cricetinae
Epithelium - metabolism
Immunohistochemistry - methods
In Situ Nick-End Labeling
Mesocricetus
Mitotic Index
Models, Animal
Mouth Neoplasms - metabolism
Mouth Neoplasms - pathology
Precancerous Conditions - metabolism
Precancerous Conditions - pathology
Tumor Suppressor Proteins - analysis
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Summary:Disruption of the homeostatic balance between proliferation and apoptosis is widely believed to contribute to human oral carcinogenesis. Using the Syrian hamster oral cancer model, we examined normal, hyperplastic, dysplastic and malignant oral epithelium for the fraction of apoptotic, proliferating and p12(doc-1) expressing keratinocytes using the TUNEL assay, as well as PCNA and p12(doc-1) immunostaining, respectively. The percentage of TUNEL positive cells progressively increased from normal to dysplastic epithelium (P
ISSN:1368-8375
DOI:10.1016/S1368-8375(01)00055-0