TUCAN/CARDINAL and DRAL participate in a common pathway for modulation of NF-kappaB activation

Proteins containing the caspase recruiting domain (CARD) have emerged as critical regulators of different signal transduction pathways, including those controlling apoptosis and activation of necrosis factor (NF)-kappaB transcription factor. TUCAN/CARDINAL is a recently identified CARD-containing pr...

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Bibliographic Details
Published in:FEBS letters 2002-06, Vol.521 (1-3), p.165
Main Authors: Stilo, Romania, Leonardi, Antonio, Formisano, Luigi, Di Jeso, Bruno, Vito, Pasquale, Liguoro, Domenico
Format: Article
Language:English
Subjects:
Adaptor Proteins, Signal Transducing
CARD Signaling Adaptor Proteins
Carrier Proteins - genetics
Carrier Proteins - metabolism
Cell Line
HeLa Cells
Homeodomain Proteins
Humans
LIM-Homeodomain Proteins
Muscle Proteins - genetics
Muscle Proteins - metabolism
Mutagenesis, Site-Directed
Neoplasm Proteins - genetics
Neoplasm Proteins - metabolism
NF-kappa B - metabolism
Proteins - metabolism
Recombinant Fusion Proteins - genetics
Recombinant Fusion Proteins - metabolism
Signal Transduction
TNF Receptor-Associated Factor 2
TNF Receptor-Associated Factor 6
Transcription Factors
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Summary:Proteins containing the caspase recruiting domain (CARD) have emerged as critical regulators of different signal transduction pathways, including those controlling apoptosis and activation of necrosis factor (NF)-kappaB transcription factor. TUCAN/CARDINAL is a recently identified CARD-containing protein involved in regulation of caspases and NF-kappaB activation. We find that TUCAN/CARDINAL associates with DRAL, a p53-responsive gene implicated in induction of apoptosis. We also show that, whereas TUCAN/CARDINAL exerts a suppressive effect on NF-kappaB activity, expression of DRAL results in enhancement of NF-kappaB activation. Thus, our observations suggest that DRAL and TUCAN/CARDINAL may participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappaB transcription factor.
ISSN:0014-5793