The influence of ethanol on the functional status of GABA(A) receptors

Gamma aminobutyric acid (GABA) is one of the main inhibitory neurotransmitters in the mammalian brain. Its effects are realized via GABA(A), GABA(B), and GABA(C) receptors. GABA(A) is the most abundant type of GABA receptors. It consists of six classes of subunits, alpha, beta, gamma, delta, epsilon...

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Bibliographic Details
Published in:Biochemistry (Moscow) 2002-07, Vol.67 (7), p.719
Main Authors: Golovko, A I, Golovko, S I, Leontieva, L V, Zefirov, S Yu
Format: Article
Language:English
Subjects:
Alcoholism - metabolism
Animals
Ethanol - administration & dosage
Ethanol - pharmacology
gamma-Aminobutyric Acid - pharmacology
Humans
Protein Subunits
Receptors, GABA - chemistry
Receptors, GABA - metabolism
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Summary:Gamma aminobutyric acid (GABA) is one of the main inhibitory neurotransmitters in the mammalian brain. Its effects are realized via GABA(A), GABA(B), and GABA(C) receptors. GABA(A) is the most abundant type of GABA receptors. It consists of six classes of subunits, alpha, beta, gamma, delta, epsilon, and chi. Acute and chronic exposures to ethanol are accompanied by changes in structure and function of GABA(A) receptors. These changes may be a basis for altered behavior seen in alcoholism.
ISSN:0006-2979
DOI:10.1023/A:1016354420673