Glycosylation Defining Cancer Malignancy: New Wine in an Old Bottle

A long-standing debate is whether aberrant glycosylation is a result or a cause of cancer. Most recent studies indicate that some, if not all, aberrant glycosylation is a result of initial oncogenic transformation, as well as a key event in induction of invasion and metastasis.

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2002-08, Vol.99 (16), p.10231-10233
Main Author: Hakomori, Senitiroh
Format: Article
Language:English
Subjects:
Adenocarcinoma - enzymology
Adenocarcinoma - genetics
Apoptosis
Cancer
Cell lines
Colonic Neoplasms - enzymology
Colonic Neoplasms - genetics
Commentaries
Epitopes
G(M3) Ganglioside - metabolism
Gangliosides
Glycosylation
Humans
Medical research
Metastasis
Neuraminidase - genetics
Phenotypes
Proto-Oncogene Proteins c-bcl-2 - metabolism
Receptors
RNA, Messenger
Tumor cell line
Tumors
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Description
Summary:A long-standing debate is whether aberrant glycosylation is a result or a cause of cancer. Most recent studies indicate that some, if not all, aberrant glycosylation is a result of initial oncogenic transformation, as well as a key event in induction of invasion and metastasis.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.172380699