Hyperhomocysteinemia in rheumatoid arthritis: influence of methotrexate treatment and folic acid supplementation

OBJECTIVE: To examine the effect of methotrexate (MTX) and folic acid supplementation on the homocysteine level in patients with rheumatoid arthritis (RA). METHODS: A cross sectional study was performed in 81 patients with RA, comprising a standardized clinical interview, an examination, and a blood...

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Bibliographic Details
Published in:Journal of rheumatology 2002-08, Vol.29 (8), p.1615-1618
Main Authors: JENSEN, Ole Kudsk, RASMUSSEN, Claus, MOLLERUP, Frank, CHRISTENSEN, Peder Bjerg, HANSEN, Henrik, EKELUND, Suzanne, THULSTRUP, Ane Marie
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antirheumatic Agents - adverse effects
Antirheumatic Agents - therapeutic use
Arthritis, Rheumatoid - blood
Arthritis, Rheumatoid - complications
Arthritis, Rheumatoid - drug therapy
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Disability Evaluation
Drug Therapy, Combination
Female
Folic Acid - administration & dosage
Folic Acid Antagonists - adverse effects
Folic Acid Antagonists - therapeutic use
Folic Acid Deficiency - blood
Folic Acid Deficiency - chemically induced
Folic Acid Deficiency - prevention & control
Health Status
Homocysteine - blood
Humans
Hyperhomocysteinemia - blood
Hyperhomocysteinemia - drug therapy
Hyperhomocysteinemia - etiology
Male
Medical sciences
Methotrexate - adverse effects
Methotrexate - therapeutic use
Middle Aged
Pharmacology. Drug treatments
Surveys and Questionnaires
Treatment Outcome
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Summary:OBJECTIVE: To examine the effect of methotrexate (MTX) and folic acid supplementation on the homocysteine level in patients with rheumatoid arthritis (RA). METHODS: A cross sectional study was performed in 81 patients with RA, comprising a standardized clinical interview, an examination, and a blood specimen test. RESULTS: P-homocysteine tended to be lower in 41 patients receiving MTX, compared with 40 patients not receiving MTX. Of the MTX treated patients, 76% received folic acid supplementation. Multivariate analysis revealed a statistically significant association between P-homocysteine and P-creatinine (p < 0.001), and disease activity/progression measured by the Health Assessment Questionnaire score (p < 0.001). There was a tendency to negative association between P-homocys-teine and folic acid supplementation. CONCLUSION: P-homocysteine in patients with RA receiving MTX and folic acid supplementation did not differ significantly from P-homocysteine in RA patients receiving other types of treatment.
ISSN:0315-162X
1499-2752