Comparison of the prevention of aflatoxin b(1)-induced genotoxicity by quercetin and quercetin pentaacetate

Earlier work carried out in our laboratory highlighted the mode of action of acetoxy 4-methylcoumarins in preventing the genotoxicity of aflatoxin B(1) (AFB(1)). We have in this report extended the observations to quercetin pentaacetate (QPA), which unlike quercetin (Q) has demonstrated time-depende...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2002-09, Vol.12 (18), p.2579
Main Authors: Kohli, Ekta, Raj, Hanumantharao G, Kumari, Ranju, Rohil, Vishwajit, Kaushik, Narendra K, Prasad, Ashok K, Parmar, Virinder S
Format: Article
Language:English
Subjects:
Aflatoxin B1 - toxicity
Animals
Antimutagenic Agents - pharmacology
Bone Marrow Cells - drug effects
Bone Marrow Cells - ultrastructure
Catalysis
Cytochrome P-450 Enzyme System - metabolism
Male
Micronucleus Tests
Microsomes, Liver - enzymology
NADPH-Ferrihemoprotein Reductase - metabolism
Quercetin - analogs & derivatives
Quercetin - pharmacology
Rats
Rats, Wistar
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Summary:Earlier work carried out in our laboratory highlighted the mode of action of acetoxy 4-methylcoumarins in preventing the genotoxicity of aflatoxin B(1) (AFB(1)). We have in this report extended the observations to quercetin pentaacetate (QPA), which unlike quercetin (Q) has demonstrated time-dependent inhibition of liver microsome catalysed AFB(1) epoxidation as measured by AFB(1) binding to DNA. The action of QPA is similar to that of the acetoxy 4-methylcoumarins in that they are acted upon by microsomal transacetylase leading to modulation of catalytic activities of certain enzymes (such as P-450 enzymes, NADPH cytochrome C reductase and glutathione S-transferase) possibly by way of protein acetylation. In the present work, we have documented the transacetylase-mediated action of QPA in preventing genotoxicity due to AFB(1).
ISSN:0960-894X