Impact of Activities OF NA+,K+-Atpase and CA2+-Atpase in the Cochlear Lateral Wall on Recovery from Noise-Induced Temporary Threshold Shift

The present study was designed to investigate the relationship between the noise-induced temporary threshold shift (TTS) and the specific activities of sodium potassium adenosine triphosphatase (Na+,K+-ATPase) and calcium adenosine triphosphatase (Ca2+-ATPase) in the cochlear lateral wall. The speci...

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Bibliographic Details
Published in:Annals of otology, rhinology & laryngology rhinology & laryngology, 2002-09, Vol.111 (9), p.842-849
Main Authors: Hsu, Chuan-Jen, Yeh, Te-Huei, Chen, Yuh-Shyang, Lee, Shiann-Yann, Shau, Wen-Yi, Lin-Shiau, Shoei Yn
Format: Article
Language:English
Subjects:
Animals
Auditory Threshold
Biological and medical sciences
Calcium-Transporting ATPases - metabolism
Cochlea - enzymology
Colorimetry
Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation
Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology
Evoked Potentials, Auditory, Brain Stem
Fundamental and applied biological sciences. Psychology
Guinea Pigs
Hearing Loss, Noise-Induced - etiology
Male
Medical sciences
Noise
Non tumoral diseases
Otorhinolaryngology. Stomatology
Sodium-Potassium-Exchanging ATPase - metabolism
Tropical medicine
Vertebrates: nervous system and sense organs
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Summary:The present study was designed to investigate the relationship between the noise-induced temporary threshold shift (TTS) and the specific activities of sodium potassium adenosine triphosphatase (Na+,K+-ATPase) and calcium adenosine triphosphatase (Ca2+-ATPase) in the cochlear lateral wall. The specific activities of these enzymes were quantified by microcolorimetric assay. Changes in auditory brain stem response (ABR) thresholds were compared with the quantitative alterations of the specific activities of Na+,K+-ATPase and Ca2+-ATPase in the cochlear lateral wall of guinea pigs with a noise-induced TTS. In the majority of those noise-exposed ears with complete recovery of ABR thresholds, the specific activities of both enzymes returned to at least 70% of the mean specific activity of the control group. Although other factors may be involved, reversible inactivation of Na+,K+-ATPase and Ca2+-ATPase in the cochlear lateral wall may be one component of the TTS. Our present findings could drive further studies on the molecular basis of noise-induced hearing loss.
ISSN:0003-4894
1943-572X
DOI:10.1177/000348940211100915