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High frequency of micronuclei in peripheral blood lymphocytes as index of susceptibility to pleural malignant mesothelioma
We evaluated the frequency of micronuclei (MN) in peripheral blood lymphocytes of patients with pleural malignant mesotelioma (MM), lung cancer, benign respiratory diseases, and healthy controls. A significant increased frequency of MN was observed in patients with MM in comparison with all the othe...
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| Published in: | Cancer research (Chicago, Ill.) Ill.), 2002-10, Vol.62 (19), p.5418-5419 |
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| Main Authors: | , , , , , , , , , |
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| Language: | English |
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| container_end_page | 5419 |
| container_issue | 19 |
| container_start_page | 5418 |
| container_title | Cancer research (Chicago, Ill.) |
| container_volume | 62 |
| creator | BOLOGNESI, Claudia FILIBERTI, Rosangela NERI, Monica PERRONE, Emanuela LANDINI, Eleonora CANESSA, Pier Aldo SIMONASSI, Claudio CERRANO, Paolo Giuseppe MUTTI, Luciano PUNTONI, Riccardo |
| description | We evaluated the frequency of micronuclei (MN) in peripheral blood lymphocytes of patients with pleural malignant mesotelioma (MM), lung cancer, benign respiratory diseases, and healthy controls. A significant increased frequency of MN was observed in patients with MM in comparison with all the other groups (median, 11.4 binucleated MN/1000 binucleated cells versus 5.1, 6.1, and 6.2, respectively). No association was found between MN and asbestos exposure. Recently, genetic susceptibility associated with asbestos exposure has been recognized in the development of MM. The presence of high frequency of MN in peripheral blood lymphocytes of patients with MM could represent a useful index of individual susceptibility to this tumor. |
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A significant increased frequency of MN was observed in patients with MM in comparison with all the other groups (median, 11.4 binucleated MN/1000 binucleated cells versus 5.1, 6.1, and 6.2, respectively). No association was found between MN and asbestos exposure. Recently, genetic susceptibility associated with asbestos exposure has been recognized in the development of MM. The presence of high frequency of MN in peripheral blood lymphocytes of patients with MM could represent a useful index of individual susceptibility to this tumor.</description><identifier>ISSN: 0008-5472</identifier><identifier>EISSN: 1538-7445</identifier><identifier>PMID: 12359747</identifier><identifier>CODEN: CNREA8</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Asbestos - adverse effects ; Biological and medical sciences ; Case-Control Studies ; Female ; Humans ; Lung Neoplasms - blood ; Lung Neoplasms - genetics ; Lymphocytes - ultrastructure ; Male ; Medical sciences ; Mesothelioma - blood ; Mesothelioma - genetics ; Micronuclei, Chromosome-Defective ; Occupational Exposure ; Pleural Neoplasms - blood ; Pleural Neoplasms - genetics ; Pneumology ; Tumors of the respiratory system and mediastinum</subject><ispartof>Cancer research (Chicago, Ill.), 2002-10, Vol.62 (19), p.5418-5419</ispartof><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13953308$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12359747$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BOLOGNESI, Claudia</creatorcontrib><creatorcontrib>FILIBERTI, Rosangela</creatorcontrib><creatorcontrib>NERI, Monica</creatorcontrib><creatorcontrib>PERRONE, Emanuela</creatorcontrib><creatorcontrib>LANDINI, Eleonora</creatorcontrib><creatorcontrib>CANESSA, Pier Aldo</creatorcontrib><creatorcontrib>SIMONASSI, Claudio</creatorcontrib><creatorcontrib>CERRANO, Paolo Giuseppe</creatorcontrib><creatorcontrib>MUTTI, Luciano</creatorcontrib><creatorcontrib>PUNTONI, Riccardo</creatorcontrib><title>High frequency of micronuclei in peripheral blood lymphocytes as index of susceptibility to pleural malignant mesothelioma</title><title>Cancer research (Chicago, Ill.)</title><addtitle>Cancer Res</addtitle><description>We evaluated the frequency of micronuclei (MN) in peripheral blood lymphocytes of patients with pleural malignant mesotelioma (MM), lung cancer, benign respiratory diseases, and healthy controls. A significant increased frequency of MN was observed in patients with MM in comparison with all the other groups (median, 11.4 binucleated MN/1000 binucleated cells versus 5.1, 6.1, and 6.2, respectively). No association was found between MN and asbestos exposure. Recently, genetic susceptibility associated with asbestos exposure has been recognized in the development of MM. The presence of high frequency of MN in peripheral blood lymphocytes of patients with MM could represent a useful index of individual susceptibility to this tumor.</description><subject>Asbestos - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Lung Neoplasms - blood</subject><subject>Lung Neoplasms - genetics</subject><subject>Lymphocytes - ultrastructure</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mesothelioma - blood</subject><subject>Mesothelioma - genetics</subject><subject>Micronuclei, Chromosome-Defective</subject><subject>Occupational Exposure</subject><subject>Pleural Neoplasms - blood</subject><subject>Pleural Neoplasms - genetics</subject><subject>Pneumology</subject><subject>Tumors of the respiratory system and mediastinum</subject><issn>0008-5472</issn><issn>1538-7445</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNpFkMFLwzAYxYMobk7_BcnFYyFpkjY7ylA3GHjR80jTL2skbWKSgvWvt8OJp8f3vd97h3eBllQwWdSci0u0JITIQvC6XKCblD7mU1AirtGClkysa14v0ffWHjtsInyOMOgJe4N7q6MfRu3AYjvgANGGDqJyuHHet9hNfei8njIkrNKMtPB1yqUxaQjZNtbZPOHscXAwnnK9cvY4qCHjHpLPHTjre3WLroxyCe7OukLvz09vm22xf33ZbR73RVfWNBcVN5IyxkirwSgiauCyopK1vJl_RCtDFJF1RYwoQdKWNswwYhpZzaYWjK3Q_W9vGJse2kOItldxOvyNMAMPZ0AlrZyJatA2_XNsPbcQyX4ABNVpmw</recordid><startdate>20021001</startdate><enddate>20021001</enddate><creator>BOLOGNESI, Claudia</creator><creator>FILIBERTI, Rosangela</creator><creator>NERI, Monica</creator><creator>PERRONE, Emanuela</creator><creator>LANDINI, Eleonora</creator><creator>CANESSA, Pier Aldo</creator><creator>SIMONASSI, Claudio</creator><creator>CERRANO, Paolo Giuseppe</creator><creator>MUTTI, Luciano</creator><creator>PUNTONI, Riccardo</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20021001</creationdate><title>High frequency of micronuclei in peripheral blood lymphocytes as index of susceptibility to pleural malignant mesothelioma</title><author>BOLOGNESI, Claudia ; FILIBERTI, Rosangela ; NERI, Monica ; PERRONE, Emanuela ; LANDINI, Eleonora ; CANESSA, Pier Aldo ; SIMONASSI, Claudio ; CERRANO, Paolo Giuseppe ; MUTTI, Luciano ; PUNTONI, Riccardo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h271t-64f813330dcefa057e486183d4b30d0caf0a08760f52e81d1b3f30fb86d0cc533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Asbestos - adverse effects</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Lung Neoplasms - blood</topic><topic>Lung Neoplasms - genetics</topic><topic>Lymphocytes - ultrastructure</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mesothelioma - blood</topic><topic>Mesothelioma - genetics</topic><topic>Micronuclei, Chromosome-Defective</topic><topic>Occupational Exposure</topic><topic>Pleural Neoplasms - blood</topic><topic>Pleural Neoplasms - genetics</topic><topic>Pneumology</topic><topic>Tumors of the respiratory system and mediastinum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BOLOGNESI, Claudia</creatorcontrib><creatorcontrib>FILIBERTI, Rosangela</creatorcontrib><creatorcontrib>NERI, Monica</creatorcontrib><creatorcontrib>PERRONE, Emanuela</creatorcontrib><creatorcontrib>LANDINI, Eleonora</creatorcontrib><creatorcontrib>CANESSA, Pier Aldo</creatorcontrib><creatorcontrib>SIMONASSI, Claudio</creatorcontrib><creatorcontrib>CERRANO, Paolo Giuseppe</creatorcontrib><creatorcontrib>MUTTI, Luciano</creatorcontrib><creatorcontrib>PUNTONI, Riccardo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Cancer research (Chicago, Ill.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BOLOGNESI, Claudia</au><au>FILIBERTI, Rosangela</au><au>NERI, Monica</au><au>PERRONE, Emanuela</au><au>LANDINI, Eleonora</au><au>CANESSA, Pier Aldo</au><au>SIMONASSI, Claudio</au><au>CERRANO, Paolo Giuseppe</au><au>MUTTI, Luciano</au><au>PUNTONI, Riccardo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High frequency of micronuclei in peripheral blood lymphocytes as index of susceptibility to pleural malignant mesothelioma</atitle><jtitle>Cancer research (Chicago, Ill.)</jtitle><addtitle>Cancer Res</addtitle><date>2002-10-01</date><risdate>2002</risdate><volume>62</volume><issue>19</issue><spage>5418</spage><epage>5419</epage><pages>5418-5419</pages><issn>0008-5472</issn><eissn>1538-7445</eissn><coden>CNREA8</coden><abstract>We evaluated the frequency of micronuclei (MN) in peripheral blood lymphocytes of patients with pleural malignant mesotelioma (MM), lung cancer, benign respiratory diseases, and healthy controls. A significant increased frequency of MN was observed in patients with MM in comparison with all the other groups (median, 11.4 binucleated MN/1000 binucleated cells versus 5.1, 6.1, and 6.2, respectively). No association was found between MN and asbestos exposure. Recently, genetic susceptibility associated with asbestos exposure has been recognized in the development of MM. The presence of high frequency of MN in peripheral blood lymphocytes of patients with MM could represent a useful index of individual susceptibility to this tumor.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>12359747</pmid><tpages>2</tpages></addata></record> |
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| identifier | ISSN: 0008-5472 |
| ispartof | Cancer research (Chicago, Ill.), 2002-10, Vol.62 (19), p.5418-5419 |
| issn | 0008-5472 1538-7445 |
| language | eng |
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| source | EZB Electronic Journals Library |
| subjects | Asbestos - adverse effects Biological and medical sciences Case-Control Studies Female Humans Lung Neoplasms - blood Lung Neoplasms - genetics Lymphocytes - ultrastructure Male Medical sciences Mesothelioma - blood Mesothelioma - genetics Micronuclei, Chromosome-Defective Occupational Exposure Pleural Neoplasms - blood Pleural Neoplasms - genetics Pneumology Tumors of the respiratory system and mediastinum |
| title | High frequency of micronuclei in peripheral blood lymphocytes as index of susceptibility to pleural malignant mesothelioma |
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