Creatine supplementation influences substrate utilization at rest

• Published in: Journal of applied physiology (1985) 2002-12, Vol.93 (6), p.2018-2022
• Main Authors: Huso, M. Erik, Hampl, Jeffrey S, Johnston, Carol S, Swan, Pamela D
• Format: Article
• Language: English
• Subjects: Adult; Biological and medical sciences; Body Composition; Carbohydrate Metabolism; Carbohydrates; Creatinine - pharmacokinetics; Creatinine - urine; Cross-Over Studies; Double-Blind Method; Exercise - physiology; Fats - metabolism; Fundamental and applied biological sciences. Psychology; Humans; Intermediate and energetic metabolism; Isometric Contraction - drug effects; Isometric Contraction - physiology; Male; Metabolisms and neurohumoral controls; Muscle, Skeletal - metabolism; Oxidation; Oxidation-Reduction; Oxygen Consumption - drug effects; Oxygen Consumption - physiology; Phosphates; Respiration; Respiratory system; Rest - physiology; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Weight Lifting - physiology
• ISSN: 8750-7587; 1522-1601
• DOI: 10.1152/japplphysiol.01170.2001

Departments of 1  Nutrition and 2  Exercise and Wellness, Arizona State University, Mesa, Arizona 85212 The influence of creatine supplementation on substrate utilization during rest was investigated using a double-blind crossover design. Ten active men participated in 12 wk of weight training and were given creatine and placebo (20 g/day for 4 days, then 2 g/day for 17 days) in two trials separated by a 4-wk washout. Body composition, substrate utilization, and strength were assessed after weeks 2, 5, 9 , and 12 . Maximal isometric contraction [1 repetition maximum (RM)] leg press increased significantly ( P