First Occurrence of Transferable Extended-Spectrum Beta-Lactamase Hydrolyzing Cefoperazone in Multiresistant Nosocomial Strains of Klebsiella pneumoniae from two Hospitals in Czech and Slovak Republics

The occurrence of positive synergy between antibiotic discs of amoxicillin/clavulanate and cefoperazone was registered in two Klebsiella pneumoniae strains, isolated from hospitals in Czech and Slovak Republic, indicating the presence of genes coding for an extended-spectrum beta-lactamase active al...

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Bibliographic Details
Published in:Journal of chemotherapy (Florence) 2002-10, Vol.14 (5), p.461-464
Main Authors: Blahová, J., Králiková, K., Krcméry, V., Vaculíková, A., Jezek, P.
Format: Article
Language:English
Subjects:
Amoxicillin-Potassium Clavulanate Combination - pharmacology
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Cefoperazone - pharmacology
Cephalosporins - pharmacology
Cross Infection - drug therapy
Czech Republic
Drug Interactions
Drug Resistance, Multiple
Escherichia coli - drug effects
Escherichia coli - genetics
Humans
Hydrolysis
Klebsiella Infections - drug therapy
Klebsiella pneumoniae - drug effects
Klebsiella pneumoniae - genetics
Klebsiella pneumoniae - pathogenicity
Medical sciences
Pharmacology. Drug treatments
Proteus mirabilis - drug effects
Proteus mirabilis - genetics
Slovakia
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Summary:The occurrence of positive synergy between antibiotic discs of amoxicillin/clavulanate and cefoperazone was registered in two Klebsiella pneumoniae strains, isolated from hospitals in Czech and Slovak Republic, indicating the presence of genes coding for an extended-spectrum beta-lactamase active also against cefoperazone, a broad-spectrum cephalosporin. Sulbactam inhibited the hydrolysis of cefoperazone by cell-free lysates of these strains which substantiates its use in combination with cefoperazone. Resistance to cephalothin, cefotaxime, ceftazidime, cefoperazone, cefepime and aztreonam was transferred from K. pneumoniae isolates to Escherichia coli K-12 3110 and to Proteus mirabilis P-38 recipient strains.
ISSN:1120-009X
1973-9478
DOI:10.1179/joc.2002.14.5.461