Loading…
Notch Signaling in Cancer
Notch signaling plays a key role in the normal development of many tissues and cell types, through diverse effects on differentiation, survival, and/or proliferation that are highly dependent on signal strength and cellular context. Because perturbations in the regulation of differentiation, surviva...
Saved in:
| Published in: | Cancer biology & therapy 2002-09, Vol.1 (5), p.466-476 |
|---|---|
| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c479t-4ddf6f26ab497ad2e30c363ed2ec07bbdba20dca3e8b6262f31dc4482153d8ba3 |
|---|---|
| cites | |
| container_end_page | 476 |
| container_issue | 5 |
| container_start_page | 466 |
| container_title | Cancer biology & therapy |
| container_volume | 1 |
| creator | Allenspach, Eric J. Maillard, Ivan Aster, Jon C. Pear, Warren S. |
| description | Notch signaling plays a key role in the normal development of many tissues and cell types, through diverse effects on differentiation, survival, and/or proliferation that are highly dependent on signal strength and cellular context. Because perturbations in the regulation of differentiation, survival, and/or proliferation underlie malignant transformation, pathophysiologic Notch signals potentially contribute to cancer development in several different ways.
Notch signaling was first linked to tumorigenesis through identification of a recurrent t(7;9)(q34;q34.3) chromosomal translocation involving the human Notch1 gene that is found in a small subset of human pre-T-cell acute lymphoblastic leukemias (T-ALL).
1
Since this discovery, aberrant Notch signaling has been suggested to be involved in a wide variety of human neoplasms. In this review, we will focus on recent studies linking aberrant Notch signaling with cancer. First, we discuss various mechanisms through which Notch signaling may influence cellular transformation. Then, we critically review literature pertaining to the role of Notch signaling in several cancers, and discuss possible therapeutic targets in the Notch pathway.
Key Words:
Notch, Cancer, Transformation, Development, Oncogene, Tumor suppressor |
| doi_str_mv | 10.4161/cbt.1.5.159 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmed_primary_12496471</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72788850</sourcerecordid><originalsourceid>FETCH-LOGICAL-c479t-4ddf6f26ab497ad2e30c363ed2ec07bbdba20dca3e8b6262f31dc4482153d8ba3</originalsourceid><addsrcrecordid>eNptkDtPwzAUhS0EolCYmFhQJxaU1G8nI6p4SRUMwGz5lWKUxMVOhfrvcdUIFqZ7hu-ee88B4ALBkiKO5kYPJSpZiVh9AE4QY6yomOCHO02qgkIqJuA0pU8IscC8PgYThGnNqUAn4PI5DOZj9upXvWp9v5r5frZQvXHxDBw1qk3ufJxT8H5_97Z4LJYvD0-L22VhqKiHglrb8AZzpWktlMWOQEM4cVkZKLS2WmFojSKu0hxz3BBkDaUVzs_ZSisyBdd733UMXxuXBtn5ZFzbqt6FTZICi6qqGMzgzR40MaQUXSPX0XcqbiWCcteEzE1IJJnMTWT6arTd6M7ZP3aMnoH5HsiHrEvah2S8y8l_0Z2dioM3rRst-X7D902InfoOsbVyUNs2xCbm0nyS5L9ffgCy5HzY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72788850</pqid></control><display><type>article</type><title>Notch Signaling in Cancer</title><source>EZB Free E-Journals</source><creator>Allenspach, Eric J. ; Maillard, Ivan ; Aster, Jon C. ; Pear, Warren S.</creator><creatorcontrib>Allenspach, Eric J. ; Maillard, Ivan ; Aster, Jon C. ; Pear, Warren S.</creatorcontrib><description>Notch signaling plays a key role in the normal development of many tissues and cell types, through diverse effects on differentiation, survival, and/or proliferation that are highly dependent on signal strength and cellular context. Because perturbations in the regulation of differentiation, survival, and/or proliferation underlie malignant transformation, pathophysiologic Notch signals potentially contribute to cancer development in several different ways.
Notch signaling was first linked to tumorigenesis through identification of a recurrent t(7;9)(q34;q34.3) chromosomal translocation involving the human Notch1 gene that is found in a small subset of human pre-T-cell acute lymphoblastic leukemias (T-ALL).
1
Since this discovery, aberrant Notch signaling has been suggested to be involved in a wide variety of human neoplasms. In this review, we will focus on recent studies linking aberrant Notch signaling with cancer. First, we discuss various mechanisms through which Notch signaling may influence cellular transformation. Then, we critically review literature pertaining to the role of Notch signaling in several cancers, and discuss possible therapeutic targets in the Notch pathway.
Key Words:
Notch, Cancer, Transformation, Development, Oncogene, Tumor suppressor</description><identifier>ISSN: 1538-4047</identifier><identifier>EISSN: 1555-8576</identifier><identifier>DOI: 10.4161/cbt.1.5.159</identifier><identifier>PMID: 12496471</identifier><language>eng</language><publisher>United States: Taylor & Francis</publisher><subject>Animals ; Binding ; Biology ; Bioscience ; Calcium ; Cancer ; Cell ; Cell Transformation, Viral ; Cycle ; Gene Expression Regulation, Neoplastic ; Humans ; Landes ; Ligands ; Membrane Proteins - metabolism ; Models, Biological ; Neoplasms - metabolism ; Oncogenic Viruses - metabolism ; Organogenesis ; Proteins ; Receptors, Notch ; Signal Transduction</subject><ispartof>Cancer biology & therapy, 2002-09, Vol.1 (5), p.466-476</ispartof><rights>Copyright © 2002 Landes Bioscience 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-4ddf6f26ab497ad2e30c363ed2ec07bbdba20dca3e8b6262f31dc4482153d8ba3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12496471$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Allenspach, Eric J.</creatorcontrib><creatorcontrib>Maillard, Ivan</creatorcontrib><creatorcontrib>Aster, Jon C.</creatorcontrib><creatorcontrib>Pear, Warren S.</creatorcontrib><title>Notch Signaling in Cancer</title><title>Cancer biology & therapy</title><addtitle>Cancer Biol Ther</addtitle><description>Notch signaling plays a key role in the normal development of many tissues and cell types, through diverse effects on differentiation, survival, and/or proliferation that are highly dependent on signal strength and cellular context. Because perturbations in the regulation of differentiation, survival, and/or proliferation underlie malignant transformation, pathophysiologic Notch signals potentially contribute to cancer development in several different ways.
Notch signaling was first linked to tumorigenesis through identification of a recurrent t(7;9)(q34;q34.3) chromosomal translocation involving the human Notch1 gene that is found in a small subset of human pre-T-cell acute lymphoblastic leukemias (T-ALL).
1
Since this discovery, aberrant Notch signaling has been suggested to be involved in a wide variety of human neoplasms. In this review, we will focus on recent studies linking aberrant Notch signaling with cancer. First, we discuss various mechanisms through which Notch signaling may influence cellular transformation. Then, we critically review literature pertaining to the role of Notch signaling in several cancers, and discuss possible therapeutic targets in the Notch pathway.
Key Words:
Notch, Cancer, Transformation, Development, Oncogene, Tumor suppressor</description><subject>Animals</subject><subject>Binding</subject><subject>Biology</subject><subject>Bioscience</subject><subject>Calcium</subject><subject>Cancer</subject><subject>Cell</subject><subject>Cell Transformation, Viral</subject><subject>Cycle</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Landes</subject><subject>Ligands</subject><subject>Membrane Proteins - metabolism</subject><subject>Models, Biological</subject><subject>Neoplasms - metabolism</subject><subject>Oncogenic Viruses - metabolism</subject><subject>Organogenesis</subject><subject>Proteins</subject><subject>Receptors, Notch</subject><subject>Signal Transduction</subject><issn>1538-4047</issn><issn>1555-8576</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNptkDtPwzAUhS0EolCYmFhQJxaU1G8nI6p4SRUMwGz5lWKUxMVOhfrvcdUIFqZ7hu-ee88B4ALBkiKO5kYPJSpZiVh9AE4QY6yomOCHO02qgkIqJuA0pU8IscC8PgYThGnNqUAn4PI5DOZj9upXvWp9v5r5frZQvXHxDBw1qk3ufJxT8H5_97Z4LJYvD0-L22VhqKiHglrb8AZzpWktlMWOQEM4cVkZKLS2WmFojSKu0hxz3BBkDaUVzs_ZSisyBdd733UMXxuXBtn5ZFzbqt6FTZICi6qqGMzgzR40MaQUXSPX0XcqbiWCcteEzE1IJJnMTWT6arTd6M7ZP3aMnoH5HsiHrEvah2S8y8l_0Z2dioM3rRst-X7D902InfoOsbVyUNs2xCbm0nyS5L9ffgCy5HzY</recordid><startdate>20020901</startdate><enddate>20020901</enddate><creator>Allenspach, Eric J.</creator><creator>Maillard, Ivan</creator><creator>Aster, Jon C.</creator><creator>Pear, Warren S.</creator><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020901</creationdate><title>Notch Signaling in Cancer</title><author>Allenspach, Eric J. ; Maillard, Ivan ; Aster, Jon C. ; Pear, Warren S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-4ddf6f26ab497ad2e30c363ed2ec07bbdba20dca3e8b6262f31dc4482153d8ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Binding</topic><topic>Biology</topic><topic>Bioscience</topic><topic>Calcium</topic><topic>Cancer</topic><topic>Cell</topic><topic>Cell Transformation, Viral</topic><topic>Cycle</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Landes</topic><topic>Ligands</topic><topic>Membrane Proteins - metabolism</topic><topic>Models, Biological</topic><topic>Neoplasms - metabolism</topic><topic>Oncogenic Viruses - metabolism</topic><topic>Organogenesis</topic><topic>Proteins</topic><topic>Receptors, Notch</topic><topic>Signal Transduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Allenspach, Eric J.</creatorcontrib><creatorcontrib>Maillard, Ivan</creatorcontrib><creatorcontrib>Aster, Jon C.</creatorcontrib><creatorcontrib>Pear, Warren S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer biology & therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Allenspach, Eric J.</au><au>Maillard, Ivan</au><au>Aster, Jon C.</au><au>Pear, Warren S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Notch Signaling in Cancer</atitle><jtitle>Cancer biology & therapy</jtitle><addtitle>Cancer Biol Ther</addtitle><date>2002-09-01</date><risdate>2002</risdate><volume>1</volume><issue>5</issue><spage>466</spage><epage>476</epage><pages>466-476</pages><issn>1538-4047</issn><eissn>1555-8576</eissn><abstract>Notch signaling plays a key role in the normal development of many tissues and cell types, through diverse effects on differentiation, survival, and/or proliferation that are highly dependent on signal strength and cellular context. Because perturbations in the regulation of differentiation, survival, and/or proliferation underlie malignant transformation, pathophysiologic Notch signals potentially contribute to cancer development in several different ways.
Notch signaling was first linked to tumorigenesis through identification of a recurrent t(7;9)(q34;q34.3) chromosomal translocation involving the human Notch1 gene that is found in a small subset of human pre-T-cell acute lymphoblastic leukemias (T-ALL).
1
Since this discovery, aberrant Notch signaling has been suggested to be involved in a wide variety of human neoplasms. In this review, we will focus on recent studies linking aberrant Notch signaling with cancer. First, we discuss various mechanisms through which Notch signaling may influence cellular transformation. Then, we critically review literature pertaining to the role of Notch signaling in several cancers, and discuss possible therapeutic targets in the Notch pathway.
Key Words:
Notch, Cancer, Transformation, Development, Oncogene, Tumor suppressor</abstract><cop>United States</cop><pub>Taylor & Francis</pub><pmid>12496471</pmid><doi>10.4161/cbt.1.5.159</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1538-4047 |
| ispartof | Cancer biology & therapy, 2002-09, Vol.1 (5), p.466-476 |
| issn | 1538-4047 1555-8576 |
| language | eng |
| recordid | cdi_pubmed_primary_12496471 |
| source | EZB Free E-Journals |
| subjects | Animals Binding Biology Bioscience Calcium Cancer Cell Cell Transformation, Viral Cycle Gene Expression Regulation, Neoplastic Humans Landes Ligands Membrane Proteins - metabolism Models, Biological Neoplasms - metabolism Oncogenic Viruses - metabolism Organogenesis Proteins Receptors, Notch Signal Transduction |
| title | Notch Signaling in Cancer |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-30T21%3A29%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Notch%20Signaling%20in%20Cancer&rft.jtitle=Cancer%20biology%20&%20therapy&rft.au=Allenspach,%20Eric%20J.&rft.date=2002-09-01&rft.volume=1&rft.issue=5&rft.spage=466&rft.epage=476&rft.pages=466-476&rft.issn=1538-4047&rft.eissn=1555-8576&rft_id=info:doi/10.4161/cbt.1.5.159&rft_dat=%3Cproquest_pubme%3E72788850%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c479t-4ddf6f26ab497ad2e30c363ed2ec07bbdba20dca3e8b6262f31dc4482153d8ba3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=72788850&rft_id=info:pmid/12496471&rfr_iscdi=true |