Hypnosis, Differential Expression of Cytokines by T-Cell Subsets, and the Hypothalamo-Pituitary-Adrenal Axis

This investigation tested the hypothesis that hypnosis can differentially modulate T-cell subsets, and that this effect is mediated by changes in hypothalamo-pituitary-adrenal (HPA) mediators. Seven healthy, highly hypnotizable volunteers participated in three one-day sessions, a baseline and two in...

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Bibliographic Details
Published in:The American journal of clinical hypnosis 2003-01, Vol.45 (3), p.179-196
Main Authors: Wood, Gary J., Bughi, Stefan, Morrison, John, Tanavoli, Sara, Tanavoli, Sohrab, Zadeh, Homayoun H.
Format: Article
Language:English
Subjects:
Adult
Cytokines
Cytokines - immunology
Female
Humans
Hypnosis
Hypothalamo-Hypophyseal System - immunology
hypothalamo-pituitary-adrenal axis
immunity
Male
neuro-endocrine
Neuroimmunomodulation
Pituitary-Adrenal System - immunology
psychoneuroimmunology
T-cell
T-Lymphocyte Subsets - immunology
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Summary:This investigation tested the hypothesis that hypnosis can differentially modulate T-cell subsets, and that this effect is mediated by changes in hypothalamo-pituitary-adrenal (HPA) mediators. Seven healthy, highly hypnotizable volunteers participated in three one-day sessions, a baseline and two intervention sessions. Hypnosis intervention entailed a standardized induction, suggestions for ego strengthening and optimally balanced functioning of the immune and neuroendocrine systems, and post-hypnotic suggestions for stress management and continued optimal balance of bodily systems. Blood samples were drawn at five time points between 8:00 a.m. and 3:00 p.m. and were analyzed for T-cell activation and intracellular cytokine expression (Interferon (IFN)-γ, Interleukin-2, Interleukin-4,) and HPA axis mediators (ACTH, Cortisol, and β-endorphin). Following hypnosis intervention, statistically significant immunological effects were noted. Specifically, the proportion of T-cells expressing IFN-γ (p = .0001) and IL-2 (p = .013) were lower after hypnosis. T-cell activation response to polyclonal stimulation was positively correlated with ACTH (p = .01) and β-endorphin (p = .001) while IFN-γ expression was correlated with levels of Cortisol (p < .001). Further controlled studies utilizing hypnosis with patients in treatment are warranted in order to examine whether an altered T-cell response can be replicated in the presence of disease.
ISSN:0002-9157
2160-0562
DOI:10.1080/00029157.2003.10403525