TNF-alpha antibodies are as effective as ischemic preconditioning in reducing infarct size in rabbits

1  Institut für Pathophysiologie, Zentrum für Innere Medizin and 2  Zentrales Tierlabor des Universitätsklinikums Essen, 45122 Essen, Federal Republic of Germany Pretreatment with tumor necrosis factor- (TNF- ) antibodies abolishes myocardial infarct size reduction by late ischemic preconditioning (...

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Bibliographic Details
Published in:American journal of physiology. Heart and circulatory physiology 2003-03, Vol.284 (3), p.H927-H930
Main Authors: Belosjorow, Sergej, Bolle, Ines, Duschin, Alexej, Heusch, Gerd, Schulz, Rainer
Format: Article
Language:English
Subjects:
Animals
Antibodies - therapeutic use
Antibody Specificity
Disease Models, Animal
Hemodynamics
Ischemic Preconditioning, Myocardial
Myocardial Infarction - pathology
Myocardial Infarction - prevention & control
Myocardial Ischemia - physiopathology
Myocardial Reperfusion
Rabbits
Survival Rate
Treatment Outcome
Tumor Necrosis Factor-alpha - analysis
Tumor Necrosis Factor-alpha - antagonists & inhibitors
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Summary:1  Institut für Pathophysiologie, Zentrum für Innere Medizin and 2  Zentrales Tierlabor des Universitätsklinikums Essen, 45122 Essen, Federal Republic of Germany Pretreatment with tumor necrosis factor- (TNF- ) antibodies abolishes myocardial infarct size reduction by late ischemic preconditioning (IP). Whether or not TNF- is also important for myocardial infarct size reduction by classic IP is unknown. Anesthetized rabbits were untreated ( group 1 , n  = 7), classically preconditioned by 5 min left coronary artery occlusion/10 min reperfusion ( group 2 , n  = 6), or pretreated with TNF- antibodies without ( group 3 , n  = 6) or with IP ( group 4 , n  = 6) before undergoing 30 min of occlusion and 180 min of reperfusion. Infarct size in group 1  was 44 ± 11 (means ± SD)% of the area at risk. With a comparable area at risk, infarct size was reduced to 13 ± 7%, 23 ± 8%, and 19 ± 12% (all P  
ISSN:0363-6135
1522-1539
DOI:10.1152/ajpheart.00374.2002