In Vivo Pharmacodynamic Evaluation of Clarithromycin in Comparison to Erythromycin

The efficacy of various dosing regimens of clarithromycin and erythromycin against recently isolated Streptococcus pneumoniae strains was determined In Vivo using two animal infection models (mouse peritonitis and thigh infection). For the thigh infection model, mice received a total dose of 4 mg/Kg...

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Bibliographic Details
Published in:Journal of chemotherapy (Florence) 2002-12, Vol.14 (6), p.584-590
Main Authors: Novelli, A., Fallani, S., Cassetta, M.I., Arrigucci, S., Mazzei, T.
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - blood
Anti-Bacterial Agents - pharmacokinetics
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Clarithromycin - administration & dosage
Clarithromycin - blood
Clarithromycin - pharmacokinetics
Drug Administration Schedule
Erythromycin - administration & dosage
Erythromycin - blood
Erythromycin - pharmacokinetics
Female
Medical sciences
Mice
Microbial Sensitivity Tests
Models, Animal
Peritonitis - drug therapy
Pharmacology. Drug treatments
Soft Tissue Infections - drug therapy
Streptococcal Infections - drug therapy
Streptococcus pneumoniae
Thigh
Treatment Outcome
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Summary:The efficacy of various dosing regimens of clarithromycin and erythromycin against recently isolated Streptococcus pneumoniae strains was determined In Vivo using two animal infection models (mouse peritonitis and thigh infection). For the thigh infection model, mice received a total dose of 4 mg/Kg of either clarithromycin or erythromycin, as a single total dose or divided into 2, 4 or 8 doses/24h. After 24h of therapy S. pneumoniae organisms were killed at 2.06 to 4.03 log 10 CFU/thigh by clarithromycin and the one- or two-dose regimens were significantly more effective than the four- or eight-dose regimens. Organism killing following 24h of therapy with erythromycin ranged from 1.13 to 2.31 log 10 CFU/thigh, with the one- or two-dose regimens significantly less effective than the four- or eight-dose regimens. In the mouse survival study, the same dose of either clarithromycin or erythromycin was given as a single total dose or divided into two or four doses with dosing intervals of 4 and 2-times the t 1/2 respectively. The results obtained in this model show that there is a significant difference in survival when clarithromycin is administered less frequently (4% deaths for the one-dose regimen in comparison to 40% deaths with the four-dose regimen, P
ISSN:1120-009X
1973-9478
DOI:10.1179/joc.2002.14.6.584