New Oplopane and Eremophilane Derivatives from Robinsonecio gerberifolius

A phytochemical study of Robinsonecio gerberifolius afforded six new sesquiterpenoids, two oplopane (1and 2) and four eremophilane derivatives (3-6). The structures of these compounds were elucidated on spectroscopic grounds, and the absolute configurations of compounds 3 and 4 were established from...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2003-02, Vol.66 (2), p.225-229
Main Authors: ARCINIEGAS, Amira, PéREZ-CASTORENA, Ana-L., REYES, Sibet, CONTRERAS, José Luis, DE VIVAR, Alfonso Romo
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Asteraceae - chemistry
Biological and medical sciences
Drug Screening Assays, Antitumor
General pharmacology
Humans
Inhibitory Concentration 50
Medical sciences
Mexico
Molecular Conformation
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plants, Medicinal - chemistry
Sesquiterpenes - chemistry
Sesquiterpenes - isolation & purification
Sesquiterpenes - pharmacology
Stereoisomerism
Tumor Cells, Cultured - drug effects
X-Ray Diffraction
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Summary:A phytochemical study of Robinsonecio gerberifolius afforded six new sesquiterpenoids, two oplopane (1and 2) and four eremophilane derivatives (3-6). The structures of these compounds were elucidated on spectroscopic grounds, and the absolute configurations of compounds 3 and 4 were established from CD analysis. The known 3beta-angeloyloxy-1,10-epoxyfuranoeremophilane (7) was also isolated, and its stereochemistry was revised. The cytotoxic activities of compounds 1-7 were determined against five human cancer cell lines.
ISSN:0163-3864
1520-6025
DOI:10.1021/np0203739