Eosinophilic pneumonia caused by mesalazine. Report of one case

A 50 years old male with a diagnosis of ulcerative colitis treated with mesalazine, developed after 2 months of treatment, cough, fever and progressive dyspnea. Chest X ray examination and CT scan showed pulmonary infiltrates in the right upper lobe that subsequently involved both lower lobes. A bio...

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Bibliographic Details
Published in:Revista medíca de Chile 2003-01, Vol.131 (1), p.81
Main Authors: Pérez, Carlos, Errázuriz, Isabel, Brockmann, Pablo, González, Sergio, Cofré, Cecilia
Format: Article
Language:Spanish
Subjects:
Anti-Inflammatory Agents - therapeutic use
Anti-Inflammatory Agents, Non-Steroidal - adverse effects
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Colitis, Ulcerative - drug therapy
Humans
Hydrocortisone - therapeutic use
Male
Mesalamine - adverse effects
Mesalamine - therapeutic use
Middle Aged
Prednisone - therapeutic use
Pulmonary Eosinophilia - chemically induced
Pulmonary Eosinophilia - diagnosis
Pulmonary Eosinophilia - drug therapy
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Summary:A 50 years old male with a diagnosis of ulcerative colitis treated with mesalazine, developed after 2 months of treatment, cough, fever and progressive dyspnea. Chest X ray examination and CT scan showed pulmonary infiltrates in the right upper lobe that subsequently involved both lower lobes. A biopsy, made through videothoracoscopy, showed an eosinophilic pneumonia. After the discontinuation of mesalazine and the use of glucocorticoids, the respiratory involvement resolved, and pulmonary infiltrates regressed. Mesalazine is widely used in the treatment of inflammatory bowel diseases. Pulmonary toxicity is an uncommon complication of mesalazine treatment. Nevertheless, this complication should be considered in patients that use it and develop respiratory symptoms.
ISSN:0034-9887