Evaluation of Laboratory Markers for the Detection of Infections in Open-heart Surgery Patients

This study compared the efficiency of interleukin-6 (IL-6), human neutrophil lipocalin (HNL), C-reactive protein (CRP) and white blood cell (WBC) count for the early detection of postoperative bacterial infections after open-heart surgery. These laboratory markers were determined preoperatively and...

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Bibliographic Details
Published in:Scandinavian journal of infectious diseases 2003-01, Vol.35 (2), p.121-126
Main Authors: Lannergård, Anders, Hersio, Kristina, Larsson, Anders, Pauksen, Karlis, Venge, Per, Ståhle, Elisabeth, Friman, Göran
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Bacterial diseases
Biological and medical sciences
Biomarkers - analysis
C-Reactive Protein - analysis
Cardiac Surgical Procedures - adverse effects
Cardiac Surgical Procedures - methods
Case-Control Studies
Coronary Artery Bypass - adverse effects
Coronary Artery Bypass - methods
Female
General aspects
Gram-Negative Bacterial Infections - diagnosis
Gram-Positive Bacterial Infections - diagnosis
Heart Valve Prosthesis Implantation - adverse effects
Heart Valve Prosthesis Implantation - methods
Humans
Infectious diseases
Interleukin-6 - blood
Leukocyte Count
Male
Medical sciences
Middle Aged
Neutrophil Activation
Probability
Prognosis
Prospective Studies
Sensitivity and Specificity
Statistics, Nonparametric
Surgical Wound Infection - diagnosis
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Summary:This study compared the efficiency of interleukin-6 (IL-6), human neutrophil lipocalin (HNL), C-reactive protein (CRP) and white blood cell (WBC) count for the early detection of postoperative bacterial infections after open-heart surgery. These laboratory markers were determined preoperatively and monitored daily during the first 6 postoperative days. Postoperative bacterial infections were diagnosed in 17 of 54 studied patients needing at least 3 d of intensive care. Patients with less than 3 d of intensive care were not studied. HNL and WBC count showed no significant differences between infected and non-infected groups, whereas both IL-6 and CRP were significantly higher in the infected group. IL-6 levels were higher (p
ISSN:0036-5548
1651-1980
DOI:10.1080/0036554021000027014