Synthesis and biological screening of 7-hydroxy-4-methyl-2H-chromen-2-one, 7-hydroxy-4,5-dimethyl-2H-chromen-2-one and their some derivatives

7-Hydroxy-4-methyl-2H-chromen-2-one (2), 7-hydroxy-4,5-dimethyl-2H-chromen-2-one (15) and their some derivatives were synthesized for exploring selected biological screening. The compounds 9 and 13 had shown high degree of cytotoxic activity. Three compound 9, 10 and 13 showed high degree of bacteri...

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Bibliographic Details
Published in:Natural product research 2003-04, Vol.17 (2), p.115
Main Authors: Khan, Khalid Mohammed, Saify, Zafar S, Begum, Saeedan, Noor, Fatima, Khan, Muhammad Zarrar, Hayat, Safdar, Choudhary, M Iqbal, Perveen, Shahnaz, Atta-Ur-Rahman, Zia-Ullah
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Artemia - drug effects
Benzopyrans - administration & dosage
Benzopyrans - chemical synthesis
Benzopyrans - pharmacology
Benzopyrans - therapeutic use
Gram-Negative Bacteria - drug effects
Gram-Positive Bacteria - drug effects
Humans
Lethal Dose 50
Microbial Sensitivity Tests
Phytotherapy
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Summary:7-Hydroxy-4-methyl-2H-chromen-2-one (2), 7-hydroxy-4,5-dimethyl-2H-chromen-2-one (15) and their some derivatives were synthesized for exploring selected biological screening. The compounds 9 and 13 had shown high degree of cytotoxic activity. Three compound 9, 10 and 13 showed high degree of bactericidal activity amongst the present series.
ISSN:1478-6419
DOI:10.1080/1478641031000103704