Evaluation of the anti-oxidative effect (in vitro) of tea [Camellia sinensis] polyphenols

Forty-three polyphenols from tea leaves were evaluated for their anti-oxidative effect against lipid peroxidation by the ferric thiocyanate method in vitro. Among these, 1,4,6-tri-O-galloyl-β-D-glucose (hydrolyzable tannin) showed the highest anti-oxidative activity against lipid peroxidation, even...

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Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2003-02, Vol.67 (2), p.396-401
Main Authors: Hashimoto, F. (Kagoshima Univ. (Japan). Faculty of Agriculture), Ono, M, Masuoka, C, Ito, Y, Sakata, Y, Shimizu, K, Nonaka, G, Nishioka, I, Nohara, T
Format: Article
Language:English
Subjects:
Acylation
antioxidant
ANTIOXIDANTS
Antioxidants - chemistry
Antioxidants - pharmacology
Biological and medical sciences
CAMELLIA SINENSIS
CHEMICAL STRUCTURE
Dimerization
EVALUATION
Flavonoids
Fundamental and applied biological sciences. Psychology
GALLATES
galloyl glucose
IN VITRO EXPERIMENTATION
Indicators and Reagents
Iron - chemistry
LEAVES
LIPID PEROXIDATION
Lipid Peroxidation - drug effects
Phenols - chemistry
Phenols - classification
Phenols - pharmacology
Polymers - chemistry
Polymers - classification
Polymers - pharmacology
polyphenol
POLYPHENOLS
Structure-Activity Relationship
TANNINS
tea
Tea - chemistry
Tea - classification
Thiocyanates - chemistry
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Summary:Forty-three polyphenols from tea leaves were evaluated for their anti-oxidative effect against lipid peroxidation by the ferric thiocyanate method in vitro. Among these, 1,4,6-tri-O-galloyl-β-D-glucose (hydrolyzable tannin) showed the highest anti-oxidative activity against lipid peroxidation, even stronger than that of 3-tert.-butyl-4-hydroxyanisole (BHA). The assay demonstrates that tea polyphenols, except for desgalloylated dimeric proanthocyanidins that possess a catechin structure in the upper unit and desgalloylated flavan-3-ols, and excepting theaflavin 3,3′-di-O-gallate, had more anti-oxidative activity than that of α-tocopherol. The chemical structure-activity relationship shows that the anti-oxidative action advanced with the condensation of two molecules of flavan-3-ols as well as with 3-O-acylation in the flavan skeleton such as that by galloyl, (3′-O-methyl)-galloyl, and p-coumaroyl groups.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.67.396