Dietary Aflatoxin Exposure and Chemoprevention of Cancer: A Clinical Review

Exposure to dietary aflatoxins is considered to be an important risk factor for the development of hepatocellular carcinoma in certain regions of the world. Significant advances have recently been made in understanding the clinical toxicology of aflatoxins. These include the development and validati...

Full description

Saved in:
Bibliographic Details
Published in:Journal of toxicology. Clinical toxicology 2003-01, Vol.41 (2), p.195-204
Main Author: Sudakin, Daniel L.
Format: Article
Language:English
Subjects:
Aflatoxin
Aflatoxins - pharmacokinetics
Aflatoxins - poisoning
Aflatoxins - toxicity
Animals
Anticarcinogenic Agents - therapeutic use
Biomarkers
Chemoprevention
Chlorophyllides - therapeutic use
Chlorophyllin
Diet
Humans
Mycotoxin
Neoplasms - chemically induced
Neoplasms - prevention & control
Oltipraz
Pyrazines - therapeutic use
Reverse Transcriptase Inhibitors - therapeutic use
Toxicokinetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Exposure to dietary aflatoxins is considered to be an important risk factor for the development of hepatocellular carcinoma in certain regions of the world. Significant advances have recently been made in understanding the clinical toxicology of aflatoxins. These include the development and validation of biomarkers of exposure and genotoxic effect. These biomarkers are currently being utilized to explore the potential that pharmaceutical interventions may have in modifying the toxicokinetics of dietary aflatoxin exposure. Preliminary results of clinical trials with the drug oltipraz suggest that it may modify the genotoxic effects of aflatoxin B1 by inhibiting bioactivation pathways and stimulating detoxification pathways. More recent results of a clinical trial with chlorophyllin suggest that this drug may have a role in preventing dietary exposure to aflatoxin B1 by reducing its oral bioavailability. The preliminary results of these chemoprevention studies may ultimately have implications for cancer prevention in high-risk populations in the future.
ISSN:0731-3810
1097-9875
DOI:10.1081/CLT-120019137