5alpha-Reduced androgens block estradiol-BSA-stimulated release of oxytocin

In this study we test the postulate that estradiol conjugated to bovine serum albumin (E-BSA) acts via receptors for the steroid-binding protein sex hormone binding globulin (SHBG) by attempting to block E-BSA-stimulated release of oxytocin with two antagonists of SHBG receptor actions: the 5alpha-r...

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Bibliographic Details
Published in:Brain research 2003-06, Vol.976 (2), p.259
Main Authors: Caldwell, Jack D, Song, Yan, Englöf, Ila, Höfle, Simone, Key, Mary, Morris, Mariana
Format: Article
Language:English
Subjects:
Androstane-3,17-diol - analogs & derivatives
Androstane-3,17-diol - pharmacology
Animals
Dihydrotestosterone - pharmacology
Drug Interactions
Estradiol - pharmacology
Female
Oxytocin - metabolism
Preoptic Area - drug effects
Preoptic Area - metabolism
Rats
Rats, Sprague-Dawley
Receptors, Cell Surface - metabolism
Serum Albumin, Bovine - pharmacology
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Summary:In this study we test the postulate that estradiol conjugated to bovine serum albumin (E-BSA) acts via receptors for the steroid-binding protein sex hormone binding globulin (SHBG) by attempting to block E-BSA-stimulated release of oxytocin with two antagonists of SHBG receptor actions: the 5alpha-reduced androgens dihydrotestosterone (DHT) and 3alpha-diol. Simultaneous superfusion with either DHT or 3alpha-diol significantly blocked E-BSA-stimulated release of oxytocin. We also found that a wide range of free 17beta-estradiol was unable to stimulate oxytocin release, suggesting that E-BSA stimulates receptors other than those for free estradiol to release oxytocin, perhaps SHBG receptors.
ISSN:0006-8993