Effect of Trapidil in Ischemia/Reperfusion Injury on Rat Small Intestine

To investigate the effect of trapidil on the intestinal ischemia-reperfusion injury, we determined malondialdehyde levels as a indicator of lipid peroxidation, nitrite and nitrate levels as reflections of nitric oxide metabolism, and histopathological findings in rats subjected to 40 min of ischemia...

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Bibliographic Details
Published in:Journal of investigative surgery 2003, Vol.16 (3), p.167-176
Main Authors: Colak, Tahsin, Polat, Ayse, Bagdatoglu, Ozlen, Kanik, Arzu, Turkmenoglu, Ozgur, Aydin, Suha
Format: Article
Language:English
Subjects:
Animals
Intestinal Diseases - drug therapy
Intestinal Diseases - metabolism
Intestinal Diseases - pathology
Intestine, Small - metabolism
Intestine, Small - pathology
Ischemia/reperfusion
Lipid Peroxidation
Male
Malondialdehyde - metabolism
Nitrates - metabolism
Nitric Oxide
Nitric Oxide Synthase - metabolism
Nitrites - metabolism
Platelet Aggregation Inhibitors - pharmacology
Rats
Rats, Wistar
Reperfusion Injury - drug therapy
Reperfusion Injury - metabolism
Reperfusion Injury - pathology
Trapidil
Trapidil - pharmacology
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Summary:To investigate the effect of trapidil on the intestinal ischemia-reperfusion injury, we determined malondialdehyde levels as a indicator of lipid peroxidation, nitrite and nitrate levels as reflections of nitric oxide metabolism, and histopathological findings in rats subjected to 40 min of ischemia and 2 h of reperfusion. Histopathological evaluation demonstrated that trapidil treatment has a protective effect on intestinal mucosa and reduces inflammatory cell infiltration in lamina propria, which is consistently noted in the untreated ischemic and reperfused intestines. Possible mechanism of this effect may be explained by the reduced lipid peroxidation (mean malondialdehyde level 3.72 &#45 0.27 vs. 6.13 &#45 0.44, p < .0001) and improved nitric oxide metabolism (mean nitrite plus nitrate 38.21 &#45 2.33 vs. 30.14 &#45 1.47, p = .022).
ISSN:0894-1939
1521-0553
DOI:10.1080/08941930390205809