Effect over time of allopurinol on noise-induced hearing loss in guinea pigs

Temporary threshold shift (TTS) and permanent threshold shift (PTS) may follow prolonged noise exposure. Several reports suggest that noise-induced damage to the cochlea may be related to the activity of reactive oxygen species (ROS). Drugs that scavenge or block ROS formation also protect the cochl...

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Bibliographic Details
Published in:International journal of audiology 2003-06, Vol.42 (4), p.227-234
Main Authors: FRANZE, Annamaria, SEQUINO, Luigi, SAULINO, Claudio, ATTANASIO, Giuseppe, MARCIANO, Elio
Format: Article
Language:English
Subjects:
Allopurinol - pharmacology
Animals
Auditory Threshold - drug effects
Biological and medical sciences
Ent. Stomatology
Evoked Potentials, Auditory, Brain Stem - drug effects
Female
Free Radical Scavengers - pharmacology
Guinea Pigs
Hearing Loss, Noise-Induced - prevention & control
Medical sciences
Pharmacology. Drug treatments
Time Factors
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Summary:Temporary threshold shift (TTS) and permanent threshold shift (PTS) may follow prolonged noise exposure. Several reports suggest that noise-induced damage to the cochlea may be related to the activity of reactive oxygen species (ROS). Drugs that scavenge or block ROS formation also protect the cochlea. Guinea pigs, treated with allopurinol, were exposed to white noise (120 dB SPL) or impulse noise (114 dB SPL) for 2 and 5 h. The protective effect of allopurinol was confirmed, but, at these levels of sound, it was present only after noise exposure up to 2 h. This study also offers evidence suggesting that allopurinol does not influence the establishment of PTS.
ISSN:1499-2027
1708-8186
DOI:10.3109/14992020309101318