Neural and Mammary Gland Defects in ErbB4 Knockout Mice Genetically Rescued from Embryonic Lethality

Mice lacking the epidermal growth factor receptor family member ErbB4 exhibit defects in cranial neural crest cell migration but die by embryonic day 11 because of defective heart development. To examine later phenotypes, we rescued the heart defects in ErbB4 mutant mice by expressing ErbB4 under a...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2003-07, Vol.100 (14), p.8281-8286
Main Authors: Tidcombe, Hester, Jackson-Fisher, Amy, Mathers, Kathleen, Stern, David F., Gassmann, Martin, Golding, Jon P.
Format: Article
Language:English
Subjects:
Animals
Antibodies
Biological Sciences
Cell Differentiation
Cell Movement
Central Nervous System - embryology
Cerebellum
Cerebellum - abnormalities
Complementary DNA
Cranial Nerves - embryology
Developmental biology
DNA, Complementary - genetics
DNA-Binding Proteins - metabolism
Embryonic and Fetal Development - genetics
Embryos
Female
Fetal Heart - growth & development
Genetics
Interneurons - pathology
Lactation
Lactation - physiology
Male
Mammary glands
Mammary Glands, Animal - abnormalities
Mice
Mice, Knockout
Mice, Transgenic
Milk Proteins
Morphogenesis - genetics
Myosins - genetics
Neural Crest - cytology
Neurology
Neuromuscular Junction - embryology
Neurons
Organ Specificity
Phenotypes
Phosphorylation
Phrenic Nerve - embryology
Pregnancy
Promoter Regions, Genetic
Protein Processing, Post-Translational
Receptor, Epidermal Growth Factor - deficiency
Receptor, Epidermal Growth Factor - genetics
Receptor, Epidermal Growth Factor - physiology
Receptor, ErbB-4
Rodents
STAT5 Transcription Factor
Trans-Activators - metabolism
Transgenes
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Description
Summary:Mice lacking the epidermal growth factor receptor family member ErbB4 exhibit defects in cranial neural crest cell migration but die by embryonic day 11 because of defective heart development. To examine later phenotypes, we rescued the heart defects in ErbB4 mutant mice by expressing ErbB4 under a cardiac-specific myosin promoter. Rescued ErbB4 mutant mice reach adulthood and are fertile. However, during pregnancy, mammary lobuloalveoli fail to differentiate correctly and lactation is defective. Rescued mice also display aberrant cranial nerve architecture and increased numbers of large interneurons within the cerebellum.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.1436402100