The radioprotective activities of turpentine-induced inflammation and alpha2-macroglobulin: the effect of dexamethasone on the radioprotective efficacy of the inflammation

This work was aimed at the radioprotective efficacy of turpentine oil (TO), alpha2-Macroglobulin (alpha2-M), Amifostine (Ami) and/or dexamethasone (Dex). These agents were administrated, alone or in combination, prior to irradiation of rats with 6.7 Gy (LD(50/30)). The survival was recorded daily fo...

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Bibliographic Details
Published in:Journal of radiation research 2003-03, Vol.44 (1), p.59
Main Authors: Sevaljević, Ljiljana, Dobrić, Silva, Bogojević, Desanka, Petrović, Miodrag, Koricanać, Goran, Vulović, Mojca, Kanazir, Dusan, Ribarac-Stepić, Nevena
Format: Article
Language:English
Subjects:
alpha-Macroglobulins - pharmacology
Amifostine - pharmacology
Animals
Dexamethasone - pharmacology
Glucocorticoids - pharmacology
Inflammation - chemically induced
Inflammation - physiopathology
Male
Radiation Protection - methods
Radiation-Protective Agents - pharmacology
Radiation-Sensitizing Agents - pharmacology
Rats
Rats, Wistar
Turpentine - pharmacology
Whole-Body Irradiation - mortality
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Summary:This work was aimed at the radioprotective efficacy of turpentine oil (TO), alpha2-Macroglobulin (alpha2-M), Amifostine (Ami) and/or dexamethasone (Dex). These agents were administrated, alone or in combination, prior to irradiation of rats with 6.7 Gy (LD(50/30)). The survival was recorded daily for 4 weeks after irradiation and body weight, peripheral leukocytes and thrombocytes were measured. The plasma concentration of alpha2-M and other acute phase proteins were determined by crossed immunoelectrophoresis. All rats receiving alpha2-M and Ami alone or in combination survived the radiation injury, whereas the rate of survival of TO-treated rats was 90%. Radiation and therapy-induced changes in the expression of acute phase protein genes were atypical for the acute phase reaction. Dex alone was lethal for 45% and 55% of control and irradiated rats, respectively. Pretreatment with 1mg Dex reduced radioprotective efficacy of TO and Ami to 30% and 40%, respectively. Given together TO and Ami provided 70% protection to rats receiving Dex. The TO and alpha2-M enhanced the rate of survival from 50% to 90% and 100%, respectively. In the presence of 1mg Dex the TO-induced radioprotectors and Ami exhibited radiosensitizing rather than radioprotecting activities.
ISSN:0449-3060