Neostigmine added to bupivacaine in axillary plexus block: which benefit?

Recent study showed that neostigmine (500 microg) by intra-articular produces postoperative analgesia without adverse effect. The author's goal was to determine whether 500 microg of neostigmine added to bupivacaine in axillary plexus block could prolonged postoperative analgesia without increa...

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Bibliographic Details
Published in:Annales françaises d'anesthésie et de réanimation 2003-06, Vol.22 (6), p.510
Main Authors: Bouderka, M A, Al-Harrar, R, Bouaggad, A, Harti, A
Format: Article
Language:fre
Subjects:
Adult
Anesthetics, Local - adverse effects
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Blood Pressure - drug effects
Bupivacaine - adverse effects
Female
Heart Rate - drug effects
Humans
Ketoprofen - therapeutic use
Lidocaine
Male
Middle Aged
Neostigmine - adverse effects
Nerve Block - adverse effects
Orthopedic Procedures
Pain Measurement
Pain, Postoperative - epidemiology
Pain, Postoperative - prevention & control
Parasympathomimetics - adverse effects
Postoperative Nausea and Vomiting - drug therapy
Postoperative Nausea and Vomiting - prevention & control
Surgery, Plastic
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Summary:Recent study showed that neostigmine (500 microg) by intra-articular produces postoperative analgesia without adverse effect. The author's goal was to determine whether 500 microg of neostigmine added to bupivacaine in axillary plexus block could prolonged postoperative analgesia without increasing the incidence of side effects. Ninety patients scheduled for orthopedic or plastic surgery with axillary plexus block were randomly assigned to one of 3 groups : group 1 (TGr n = 30) received saline solution (1 ml) in the axillary plexus, group 2 (NAGr n = 30) received 500 microg (1 ml) neostigmine in the axillary plexus and group 3.500 microg neostigmine subcutaneously (NSGr n = 30). We evaluated visual analog pain scores (VAS), the consumption of the ketoprofene, nausea and vomiting incidence during the first 24 h. ANOVA, Kruskall Wallis and Fisher tests were used for statistical analysis. A p value of
ISSN:0750-7658
DOI:10.1016/S0750-7658(03)00184-9