Secondary Disease in Rat Radiation Chimeras

Rats were treated with homologous bone marrow following nearly lethal and lethal X irradiation. About 60 percent of the animals survived beyond the 4th week. In the rat-strain combination used, secondary disease developed during the 2d and 3d month in about 30 percent of the survivors, with emaciati...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1964-02, Vol.32 (2), p.419-459
Main Authors: Balner, H., de Vries, M. J., van Bekkum, D. W.
Format: Article
Language:English
Subjects:
Allergy and Immunology
Anemia
Anemia, Hemolytic
Blood Cell Count
Bone Marrow Transplantation
Colitis
Dermatology
Diarrhea
Emaciation
Lymph Nodes
Pathology
Radiation Chimera
Radiation Genetics
Radiation Injuries
Radiation Injuries, Experimental
Rats
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Summary:Rats were treated with homologous bone marrow following nearly lethal and lethal X irradiation. About 60 percent of the animals survived beyond the 4th week. In the rat-strain combination used, secondary disease developed during the 2d and 3d month in about 30 percent of the survivors, with emaciation and skin lesions as the principal symptoms. Surprisingly, colitis and diarrhea, prominent and consistent symptoms of secondary disease in the other species so far investigated, were never found, even in fatal secondary disease of the rat. There was no evidence of hemolytic anemia. The administration of homologous lymphoid cells provoked a faster, somewhat modified secondary syndrome with much higher mortality. In these rats, histologic lesions of the intestinal mucosa were found, but no colitis or diarrhea. Homologous bone marrow was also administered after median lethal radiation doses, which resulted in a temporarily functioning graft. A detrimental effect of such grafts, as described for certain mouse-strain combinations (“the MLD effect”), was not found.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/32.2.419