Deaza- and Deoxyadenosine Derivatives: Synthesis and Inhibition of Animal Viruses as Human Infection Models

N 6 -Cycloalkyl-2′,3′-dideoxyadenosine derivatives and (2-chloro)-N 6 -cycloheptyl-3-deazaadenosine have been synthesized and tested, along with other (deaza)purine (deoxy)nucleosides from our chemical library, as inhibitors of virus replication against Bovine Herpes Virus 1 (BHV-1) and sheep Maedi/...

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Bibliographic Details
Published in:Nucleosides, nucleotides & nucleic acids nucleotides & nucleic acids, 2003-10, Vol.22 (5-8), p.877-881
Main Authors: Vittori, Sauro, Salvatori, Daniela, Volpini, Rosaria, Vincenzetti, Silvia, Vita, Alberto, Taffi, Sara, Costanzi, Stefano, Lambertucci, Catia, Cristalli, Gloria
Format: Article
Language:English
Subjects:
Animals
Antiviral Agents - chemical synthesis
Antiviral Agents - pharmacology
Antivirals
Bovine Herpes Virus 1
Cattle
Cell Survival - drug effects
Deazaadenosine derivatives
Deoxyadenosine derivatives
Deoxyadenosines - chemical synthesis
Deoxyadenosines - pharmacology
Disease Models, Animal
Herpesvirus 1, Bovine - drug effects
Humans
Maedi Visna Virus
Models, Molecular
Molecular Structure
Sheep
Tubercidin - analogs & derivatives
Tubercidin - chemical synthesis
Tubercidin - pharmacology
Virus Diseases - drug therapy
Virus Replication - drug effects
Visna-maedi virus - drug effects
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Summary:N 6 -Cycloalkyl-2′,3′-dideoxyadenosine derivatives and (2-chloro)-N 6 -cycloheptyl-3-deazaadenosine have been synthesized and tested, along with other (deaza)purine (deoxy)nucleosides from our chemical library, as inhibitors of virus replication against Bovine Herpes Virus 1 (BHV-1) and sheep Maedi/Visna Virus (MVV). Most compounds demonstrated good antireplicative activity against MVV, showing also low cell toxicity.
ISSN:1525-7770
1532-2335
DOI:10.1081/NCN-120022676