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Deaza- and Deoxyadenosine Derivatives: Synthesis and Inhibition of Animal Viruses as Human Infection Models
N 6 -Cycloalkyl-2′,3′-dideoxyadenosine derivatives and (2-chloro)-N 6 -cycloheptyl-3-deazaadenosine have been synthesized and tested, along with other (deaza)purine (deoxy)nucleosides from our chemical library, as inhibitors of virus replication against Bovine Herpes Virus 1 (BHV-1) and sheep Maedi/...
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| Published in: | Nucleosides, nucleotides & nucleic acids nucleotides & nucleic acids, 2003-10, Vol.22 (5-8), p.877-881 |
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| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c338t-d5b1c4590cbc1e2b2f200b9590dd914de99882798b95e7b4e19841c9c0d13a2d3 |
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| cites | cdi_FETCH-LOGICAL-c338t-d5b1c4590cbc1e2b2f200b9590dd914de99882798b95e7b4e19841c9c0d13a2d3 |
| container_end_page | 881 |
| container_issue | 5-8 |
| container_start_page | 877 |
| container_title | Nucleosides, nucleotides & nucleic acids |
| container_volume | 22 |
| creator | Vittori, Sauro Salvatori, Daniela Volpini, Rosaria Vincenzetti, Silvia Vita, Alberto Taffi, Sara Costanzi, Stefano Lambertucci, Catia Cristalli, Gloria |
| description | N
6
-Cycloalkyl-2′,3′-dideoxyadenosine derivatives and (2-chloro)-N
6
-cycloheptyl-3-deazaadenosine have been synthesized and tested, along with other (deaza)purine (deoxy)nucleosides from our chemical library, as inhibitors of virus replication against Bovine Herpes Virus 1 (BHV-1) and sheep Maedi/Visna Virus (MVV). Most compounds demonstrated good antireplicative activity against MVV, showing also low cell toxicity. |
| doi_str_mv | 10.1081/NCN-120022676 |
| format | article |
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-Cycloalkyl-2′,3′-dideoxyadenosine derivatives and (2-chloro)-N
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| fulltext | fulltext |
| identifier | ISSN: 1525-7770 |
| ispartof | Nucleosides, nucleotides & nucleic acids, 2003-10, Vol.22 (5-8), p.877-881 |
| issn | 1525-7770 1532-2335 |
| language | eng |
| recordid | cdi_pubmed_primary_14565301 |
| source | Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Science and Technology Collection (Reading list) |
| subjects | Animals Antiviral Agents - chemical synthesis Antiviral Agents - pharmacology Antivirals Bovine Herpes Virus 1 Cattle Cell Survival - drug effects Deazaadenosine derivatives Deoxyadenosine derivatives Deoxyadenosines - chemical synthesis Deoxyadenosines - pharmacology Disease Models, Animal Herpesvirus 1, Bovine - drug effects Humans Maedi Visna Virus Models, Molecular Molecular Structure Sheep Tubercidin - analogs & derivatives Tubercidin - chemical synthesis Tubercidin - pharmacology Virus Diseases - drug therapy Virus Replication - drug effects Visna-maedi virus - drug effects |
| title | Deaza- and Deoxyadenosine Derivatives: Synthesis and Inhibition of Animal Viruses as Human Infection Models |
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