Design and Synthesis of A3 Adenosine Receptor Ligands, 3′-Fluoro Analogues of Cl-IB-MECA

Synthesis of 3′-deoxy-3′-fluoro-N 6 -substituted adenosines as bioisosteres of Cl-IB-MECA and their binding affinities to A 3 adenosine receptor are described.

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Bibliographic Details
Published in:Nucleosides, nucleotides & nucleic acids nucleotides & nucleic acids, 2003-05, Vol.22 (5-8), p.923-925
Main Authors: Kim, Hea Ok, Lim, Moo Hong, Park, Jae Gyu, Moon, Hyung Ryong, Jacobson, Kenneth A., Kim, Hee-Doo, Chun, Moon Woo, Jeong, Lak Shin
Format: Article
Language:English
Subjects:
3′-Deoxy-3′-fluoro-N
Adenosine - analogs & derivatives
Adenosine - chemical synthesis
Adenosine - pharmacokinetics
adenosine receptor
Animals
Brain - metabolism
Drug Design
Fluorides
Humans
Indicators and Reagents
Ligands
Molecular Structure
Radioligand Assay
Rats
Receptor, Adenosine A3 - metabolism
substituted adenosines
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Description
Summary:Synthesis of 3′-deoxy-3′-fluoro-N 6 -substituted adenosines as bioisosteres of Cl-IB-MECA and their binding affinities to A 3 adenosine receptor are described.
ISSN:1525-7770
1532-2335
DOI:10.1081/NCN-120022701