Synthesis of Oligonucleotide Prodrugs Bearing N-Acetyl Nucleobases

N-Acetyl oligonucleotides and their prodrugs were synthesized on photolabile solid support. Tm studies showed a decrease of hydridization for N-acetyl A and G and an increase for N-acetyl C. In cells extract, acetyl groups were hydrolysed.

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Bibliographic Details
Published in:Nucleosides, nucleotides & nucleic acids nucleotides & nucleic acids, 2003-10, Vol.22 (5-8), p.1243-1245
Main Authors: Brès, J.-C., Imbach, J.-L., Morvan, F.
Format: Article
Language:English
Subjects:
Acetylation
Base Sequence
Base-sensitive
Enzymolabile
Hydrolysis
Indicators and Reagents
Nucleic Acid Conformation
Nucleosides - chemistry
Oligonucleotides - chemical synthesis
Oligonucleotides - chemistry
Prodrugs - chemical synthesis
Prodrugs - chemistry
Protecting group
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
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Description
Summary:N-Acetyl oligonucleotides and their prodrugs were synthesized on photolabile solid support. Tm studies showed a decrease of hydridization for N-acetyl A and G and an increase for N-acetyl C. In cells extract, acetyl groups were hydrolysed.
ISSN:1525-7770
1532-2335
DOI:10.1081/NCN-120022846