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Synthesis of Oligonucleotide Prodrugs Bearing N-Acetyl Nucleobases
N-Acetyl oligonucleotides and their prodrugs were synthesized on photolabile solid support. Tm studies showed a decrease of hydridization for N-acetyl A and G and an increase for N-acetyl C. In cells extract, acetyl groups were hydrolysed.
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| Published in: | Nucleosides, nucleotides & nucleic acids nucleotides & nucleic acids, 2003-10, Vol.22 (5-8), p.1243-1245 |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c340t-b2df8543c6857731abd5756f4fb2722dc378a69dae44a7b6264088974674432e3 |
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| cites | cdi_FETCH-LOGICAL-c340t-b2df8543c6857731abd5756f4fb2722dc378a69dae44a7b6264088974674432e3 |
| container_end_page | 1245 |
| container_issue | 5-8 |
| container_start_page | 1243 |
| container_title | Nucleosides, nucleotides & nucleic acids |
| container_volume | 22 |
| creator | Brès, J.-C. Imbach, J.-L. Morvan, F. |
| description | N-Acetyl oligonucleotides and their prodrugs were synthesized on photolabile solid support. Tm studies showed a decrease of hydridization for N-acetyl A and G and an increase for N-acetyl C. In cells extract, acetyl groups were hydrolysed. |
| doi_str_mv | 10.1081/NCN-120022846 |
| format | article |
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Tm studies showed a decrease of hydridization for N-acetyl A and G and an increase for N-acetyl C. In cells extract, acetyl groups were hydrolysed.</description><subject>Acetylation</subject><subject>Base Sequence</subject><subject>Base-sensitive</subject><subject>Enzymolabile</subject><subject>Hydrolysis</subject><subject>Indicators and Reagents</subject><subject>Nucleic Acid Conformation</subject><subject>Nucleosides - chemistry</subject><subject>Oligonucleotides - chemical synthesis</subject><subject>Oligonucleotides - chemistry</subject><subject>Prodrugs - chemical synthesis</subject><subject>Prodrugs - chemistry</subject><subject>Protecting group</subject><subject>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization</subject><issn>1525-7770</issn><issn>1532-2335</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNpt0DtPwzAYhWELgWgpjKwoE1vAdztjW3GTqhQJmC3HdkpQEhc7Ecq_J6UVLEz28HxneAG4RPAGQYlu82WeIgwhxpLyIzBFjOAUE8KOd3_MUiEEnICzGD8gRBJKcQomiDLOSAanYPEytN27i1VMfJms62rj297UzneVdclz8Db0m5gsnA5Vu0nydG5cN9RJ_oMKHV08ByelrqO7OLwz8HZ_97p8TFfrh6flfJUaQmGXFtiWklFiuGRCEKQLywTjJS0LLDC2hgipeWa1o1SLgmNOoZSZoFxQSrAjM3C9390G_9m72KmmisbVtW6d76MSCGfZeDPCdA9N8DEGV6ptqBodBoWg2kVTYzT1G230V4fhvmic_dOHSiOQe1C1pQ-N_vKhtqrTQ-1DGXRrqqjI_9vfJrB4aA</recordid><startdate>20031001</startdate><enddate>20031001</enddate><creator>Brès, J.-C.</creator><creator>Imbach, J.-L.</creator><creator>Morvan, F.</creator><general>Taylor & Francis Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20031001</creationdate><title>Synthesis of Oligonucleotide Prodrugs Bearing N-Acetyl Nucleobases</title><author>Brès, J.-C. ; Imbach, J.-L. ; Morvan, F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c340t-b2df8543c6857731abd5756f4fb2722dc378a69dae44a7b6264088974674432e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Acetylation</topic><topic>Base Sequence</topic><topic>Base-sensitive</topic><topic>Enzymolabile</topic><topic>Hydrolysis</topic><topic>Indicators and Reagents</topic><topic>Nucleic Acid Conformation</topic><topic>Nucleosides - chemistry</topic><topic>Oligonucleotides - chemical synthesis</topic><topic>Oligonucleotides - chemistry</topic><topic>Prodrugs - chemical synthesis</topic><topic>Prodrugs - chemistry</topic><topic>Protecting group</topic><topic>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brès, J.-C.</creatorcontrib><creatorcontrib>Imbach, J.-L.</creatorcontrib><creatorcontrib>Morvan, F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nucleosides, nucleotides & nucleic acids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brès, J.-C.</au><au>Imbach, J.-L.</au><au>Morvan, F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis of Oligonucleotide Prodrugs Bearing N-Acetyl Nucleobases</atitle><jtitle>Nucleosides, nucleotides & nucleic acids</jtitle><addtitle>Nucleosides Nucleotides Nucleic Acids</addtitle><date>2003-10-01</date><risdate>2003</risdate><volume>22</volume><issue>5-8</issue><spage>1243</spage><epage>1245</epage><pages>1243-1245</pages><issn>1525-7770</issn><eissn>1532-2335</eissn><abstract>N-Acetyl oligonucleotides and their prodrugs were synthesized on photolabile solid support. Tm studies showed a decrease of hydridization for N-acetyl A and G and an increase for N-acetyl C. In cells extract, acetyl groups were hydrolysed.</abstract><cop>United States</cop><pub>Taylor & Francis Group</pub><pmid>14565390</pmid><doi>10.1081/NCN-120022846</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 1525-7770 |
| ispartof | Nucleosides, nucleotides & nucleic acids, 2003-10, Vol.22 (5-8), p.1243-1245 |
| issn | 1525-7770 1532-2335 |
| language | eng |
| recordid | cdi_pubmed_primary_14565390 |
| source | Taylor and Francis Science and Technology Collection |
| subjects | Acetylation Base Sequence Base-sensitive Enzymolabile Hydrolysis Indicators and Reagents Nucleic Acid Conformation Nucleosides - chemistry Oligonucleotides - chemical synthesis Oligonucleotides - chemistry Prodrugs - chemical synthesis Prodrugs - chemistry Protecting group Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization |
| title | Synthesis of Oligonucleotide Prodrugs Bearing N-Acetyl Nucleobases |
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