Antibacterial effect of two glycine betaine analogues against Escherichia coli

Strains of enterobacteria that cause urinary tract infections are able to grow in urine with high tonicity. In such conditions bacterias adapt to osmotic forces by incorporation of osmoprotectant compounds including glycine betaine. Accumulation of toxic analogues in bacteria, using inducible betain...

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Bibliographic Details
Published in:Pathologie biologie (Paris) 2003-10, Vol.51 (8-9), p.516
Main Authors: Quéau, M, Renault, J, Uriac, P, Corbel, J-C, Travert, M-F, Bernard, T, Donnio, P-Y
Format: Article
Language:fre
Subjects:
Anti-Bacterial Agents - pharmacology
Betaine - analogs & derivatives
Betaine - pharmacology
Escherichia coli - drug effects
Microbial Sensitivity Tests
Stress, Mechanical
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Summary:Strains of enterobacteria that cause urinary tract infections are able to grow in urine with high tonicity. In such conditions bacterias adapt to osmotic forces by incorporation of osmoprotectant compounds including glycine betaine. Accumulation of toxic analogues in bacteria, using inducible betaine transporters, has been previously proposed for development of antibiotics. In this study we report antibacterial effect of two analogues against 82 strains of Escherichia coli isolated form urinary tract infections. Minimal inhibitory concentrations have been measured with and without osmotic stress. The betaine analogues have antibacterial effect against E. coli strains, but only in presence of an osmotic stress.
ISSN:0369-8114
DOI:10.1016/S0369-8114(03)00168-8