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Effects of enalapril on adriamycin-induced nephrosis
Adriamycin induces proteinuria and glomerular changes in rats similar to those found in human focal segmental glomerulosclerosis (FSGS). Progression of this lesion may be slowed by use of angiotensin converting enzyme inhibition. To evaluate this we injected two groups of Sprague-Dawley rats with Ad...
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| Published in: | Pediatric nephrology (Berlin, West) West), 1992-09, Vol.6 (5), p.448-450 |
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| Language: | English |
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| container_end_page | 450 |
| container_issue | 5 |
| container_start_page | 448 |
| container_title | Pediatric nephrology (Berlin, West) |
| container_volume | 6 |
| creator | IRWIN, K. C BROUHARD, B. H SATOH, S STOWE, N. T |
| description | Adriamycin induces proteinuria and glomerular changes in rats similar to those found in human focal segmental glomerulosclerosis (FSGS). Progression of this lesion may be slowed by use of angiotensin converting enzyme inhibition. To evaluate this we injected two groups of Sprague-Dawley rats with Adriamycin (2 intravenous doses of 2 mg/kg given at an interval of 3 weeks). One group of rats received enalapril (50 mg/l) in their drinking water. Control rats were injected with saline. After 28 weeks, the mean whole kidney glomerular filtration rate was significantly less and proteinuria and sclerotic index were significantly greater in rats receiving adriamycin compared with controls (P < 0.05). Administration of enalapril did not decrease proteinuria (545 +/- 398 mg/day vs 494 +/- 325 mg/day, P >0.05) or improve the glomerular filtration rate (0.31 +/- 0.18 ml/min per g kidney weight vs 0.41 +/- 0.21 ml/min per g, P = 0.27). However, treatment with enalapril significantly reduced the mean glomerular sclerotic index compared with untreated rats (1.62 +/- 0.88 vs 0.82 +/- 0.49, P = 0.05). Enalapril may be beneficial in preserving glomerular structure in this experimental model of FSGS. |
| doi_str_mv | 10.1007/BF00874011 |
| format | article |
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Administration of enalapril did not decrease proteinuria (545 +/- 398 mg/day vs 494 +/- 325 mg/day, P >0.05) or improve the glomerular filtration rate (0.31 +/- 0.18 ml/min per g kidney weight vs 0.41 +/- 0.21 ml/min per g, P = 0.27). However, treatment with enalapril significantly reduced the mean glomerular sclerotic index compared with untreated rats (1.62 +/- 0.88 vs 0.82 +/- 0.49, P = 0.05). Enalapril may be beneficial in preserving glomerular structure in this experimental model of FSGS.</description><identifier>ISSN: 0931-041X</identifier><identifier>EISSN: 1432-198X</identifier><identifier>DOI: 10.1007/BF00874011</identifier><identifier>PMID: 1457325</identifier><identifier>CODEN: PENED3</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Administration, Oral ; Animals ; Biological and medical sciences ; Disease Models, Animal ; Doxorubicin ; Enalapril - administration & dosage ; Enalapril - therapeutic use ; Glomerular Filtration Rate - physiology ; Glomerulosclerosis, Focal Segmental - chemically induced ; Glomerulosclerosis, Focal Segmental - drug therapy ; Glomerulosclerosis, Focal Segmental - pathology ; Hemodynamics - physiology ; Injections, Intravenous ; Kidney - drug effects ; Kidney - physiology ; Male ; Medical sciences ; Nephrology. 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H</creatorcontrib><creatorcontrib>SATOH, S</creatorcontrib><creatorcontrib>STOWE, N. T</creatorcontrib><title>Effects of enalapril on adriamycin-induced nephrosis</title><title>Pediatric nephrology (Berlin, West)</title><addtitle>Pediatr Nephrol</addtitle><description>Adriamycin induces proteinuria and glomerular changes in rats similar to those found in human focal segmental glomerulosclerosis (FSGS). Progression of this lesion may be slowed by use of angiotensin converting enzyme inhibition. To evaluate this we injected two groups of Sprague-Dawley rats with Adriamycin (2 intravenous doses of 2 mg/kg given at an interval of 3 weeks). One group of rats received enalapril (50 mg/l) in their drinking water. Control rats were injected with saline. After 28 weeks, the mean whole kidney glomerular filtration rate was significantly less and proteinuria and sclerotic index were significantly greater in rats receiving adriamycin compared with controls (P < 0.05). Administration of enalapril did not decrease proteinuria (545 +/- 398 mg/day vs 494 +/- 325 mg/day, P >0.05) or improve the glomerular filtration rate (0.31 +/- 0.18 ml/min per g kidney weight vs 0.41 +/- 0.21 ml/min per g, P = 0.27). However, treatment with enalapril significantly reduced the mean glomerular sclerotic index compared with untreated rats (1.62 +/- 0.88 vs 0.82 +/- 0.49, P = 0.05). Enalapril may be beneficial in preserving glomerular structure in this experimental model of FSGS.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Disease Models, Animal</subject><subject>Doxorubicin</subject><subject>Enalapril - administration & dosage</subject><subject>Enalapril - therapeutic use</subject><subject>Glomerular Filtration Rate - physiology</subject><subject>Glomerulosclerosis, Focal Segmental - chemically induced</subject><subject>Glomerulosclerosis, Focal Segmental - drug therapy</subject><subject>Glomerulosclerosis, Focal Segmental - pathology</subject><subject>Hemodynamics - physiology</subject><subject>Injections, Intravenous</subject><subject>Kidney - drug effects</subject><subject>Kidney - physiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nephrosis - chemically induced</subject><subject>Nephrosis - drug therapy</subject><subject>Organ Size</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><issn>0931-041X</issn><issn>1432-198X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><recordid>eNo9jk1LAzEURYModaxu3AuzcBvNy-dkqaVVoeCmi-5KmuRhZCYdJu2i_94RB-HCXZzL4RJyD-wJGDPPryvGGiMZwAWpQApOwTbbS1IxK4AyCdtrclPKNxtnqtEzMgOpjOCqInKJGP2x1AesY3at64fU1odcuzAk1519yjTlcPIx1Dn2X8OhpHJLrtC1Jd5NPSeb1XKzeKfrz7ePxcua9qDNkSKid8Kjt1IFyxutfeRG-sYLb8YgRMHZ3moeAzLFVdANIEfrIDBpxZw8_Gn7076LYTde69xw3k3nR_44cVe8a3Fw2afyP5NCwa_mB1IGUg8</recordid><startdate>19920901</startdate><enddate>19920901</enddate><creator>IRWIN, K. C</creator><creator>BROUHARD, B. H</creator><creator>SATOH, S</creator><creator>STOWE, N. 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T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p167t-fffca3cfc945d92866ce274c8c3c73c7f1e320b962edf0525d681f2f9a1d0493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Administration, Oral</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Disease Models, Animal</topic><topic>Doxorubicin</topic><topic>Enalapril - administration & dosage</topic><topic>Enalapril - therapeutic use</topic><topic>Glomerular Filtration Rate - physiology</topic><topic>Glomerulosclerosis, Focal Segmental - chemically induced</topic><topic>Glomerulosclerosis, Focal Segmental - drug therapy</topic><topic>Glomerulosclerosis, Focal Segmental - pathology</topic><topic>Hemodynamics - physiology</topic><topic>Injections, Intravenous</topic><topic>Kidney - drug effects</topic><topic>Kidney - physiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Nephrosis - chemically induced</topic><topic>Nephrosis - drug therapy</topic><topic>Organ Size</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>IRWIN, K. C</creatorcontrib><creatorcontrib>BROUHARD, B. H</creatorcontrib><creatorcontrib>SATOH, S</creatorcontrib><creatorcontrib>STOWE, N. T</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Pediatric nephrology (Berlin, West)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>IRWIN, K. C</au><au>BROUHARD, B. H</au><au>SATOH, S</au><au>STOWE, N. T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of enalapril on adriamycin-induced nephrosis</atitle><jtitle>Pediatric nephrology (Berlin, West)</jtitle><addtitle>Pediatr Nephrol</addtitle><date>1992-09-01</date><risdate>1992</risdate><volume>6</volume><issue>5</issue><spage>448</spage><epage>450</epage><pages>448-450</pages><issn>0931-041X</issn><eissn>1432-198X</eissn><coden>PENED3</coden><abstract>Adriamycin induces proteinuria and glomerular changes in rats similar to those found in human focal segmental glomerulosclerosis (FSGS). Progression of this lesion may be slowed by use of angiotensin converting enzyme inhibition. To evaluate this we injected two groups of Sprague-Dawley rats with Adriamycin (2 intravenous doses of 2 mg/kg given at an interval of 3 weeks). One group of rats received enalapril (50 mg/l) in their drinking water. Control rats were injected with saline. After 28 weeks, the mean whole kidney glomerular filtration rate was significantly less and proteinuria and sclerotic index were significantly greater in rats receiving adriamycin compared with controls (P < 0.05). Administration of enalapril did not decrease proteinuria (545 +/- 398 mg/day vs 494 +/- 325 mg/day, P >0.05) or improve the glomerular filtration rate (0.31 +/- 0.18 ml/min per g kidney weight vs 0.41 +/- 0.21 ml/min per g, P = 0.27). However, treatment with enalapril significantly reduced the mean glomerular sclerotic index compared with untreated rats (1.62 +/- 0.88 vs 0.82 +/- 0.49, P = 0.05). Enalapril may be beneficial in preserving glomerular structure in this experimental model of FSGS.</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>1457325</pmid><doi>10.1007/BF00874011</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0931-041X |
| ispartof | Pediatric nephrology (Berlin, West), 1992-09, Vol.6 (5), p.448-450 |
| issn | 0931-041X 1432-198X |
| language | eng |
| recordid | cdi_pubmed_primary_1457325 |
| source | SpringerLink_过刊（NSTL购买） |
| subjects | Administration, Oral Animals Biological and medical sciences Disease Models, Animal Doxorubicin Enalapril - administration & dosage Enalapril - therapeutic use Glomerular Filtration Rate - physiology Glomerulosclerosis, Focal Segmental - chemically induced Glomerulosclerosis, Focal Segmental - drug therapy Glomerulosclerosis, Focal Segmental - pathology Hemodynamics - physiology Injections, Intravenous Kidney - drug effects Kidney - physiology Male Medical sciences Nephrology. Urinary tract diseases Nephrosis - chemically induced Nephrosis - drug therapy Organ Size Rats Rats, Sprague-Dawley |
| title | Effects of enalapril on adriamycin-induced nephrosis |
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