The effect of antenatal corticosteroids on gut peptides of preterm infants—a matched group comparison: Corticosteroids and gut development

Background: Postnatal glucocorticosteroid administration has trophic effects on the gastrointestinal tract of preterm infants. The aim of the present study was to investigate whether antenatal glucocorticosteroids affect the secretion of gastrointestinal peptides that are involved in the regulation...

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Bibliographic Details
Published in:Early human development 2003-11, Vol.74 (2), p.83-88
Main Authors: Costalos, C., Gounaris, A., Sevastiadou, S., Hatzistamatiou, Z., Theodoraki, M., Alexiou, E.N., Constandellou, E.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Corticosteroids
Dexamethasone - administration & dosage
Digestive System - drug effects
Digestive System - embryology
Digestive System - metabolism
Embryology: invertebrates and vertebrates. Teratology
Enteral Nutrition
Female
Fundamental and applied biological sciences. Psychology
Gastrins - blood
Gestational Age
Glucocorticoids - administration & dosage
Gut hormones
Humans
Infant, Newborn
Infant, Premature - blood
Male
Maternal Exposure
Motilin - blood
Organogenesis. Physiological fonctions
Physiological fonctions
Pregnancy
Prenatal Exposure Delayed Effects
Preterm infants
Vasoactive Intestinal Peptide - blood
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Summary:Background: Postnatal glucocorticosteroid administration has trophic effects on the gastrointestinal tract of preterm infants. The aim of the present study was to investigate whether antenatal glucocorticosteroids affect the secretion of gastrointestinal peptides that are involved in the regulation of secretion, motility and mucosal protection of the gastrointestinal tract. Methods: Plasma levels of gastrin, motilin and vasoactive intestinal peptide (VIP) were estimated in 28 preterm infants with a mean birth weight of 1280 g, and mean gestational age of 30.5 weeks, whose mothers had received a full course of antenatal glucocorticosteroids (GC group) and in 17 preterm infants with mean birth weight of 1200 g, mean gestational age of 30.2 weeks, whose mothers had not received corticosteroids (control group). GI peptides were estimated on two occasions: (a) Immediately after birth and (b) following the initiation of enteral feeding. Results: Gastrin levels in the GC group were significantly higher both immediately after birth (early measurement) and also after receiving enteral feeding (late measurement) ( p
ISSN:0378-3782
1872-6232
DOI:10.1016/S0378-3782(03)00087-2