A Computer-Based Model for the Regulation of Mitogen Activated Protein Kinase (MAPK) Activation

Abstract Computer simulations and mathematical modeling of biological processes are becoming increasingly popular, and yet the complexity of the biochemical systems or the differences between experimental setups make it very difficult to establish a standard formula for these modeling projects. Befo...

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Bibliographic Details
Published in:Journal of receptors and signal transduction 2003, Vol.23 (2-3), p.197-209
Main Authors: Aksan, Isil, Levent Kurnaz, M.
Format: Article
Language:English
Subjects:
Animals
Computer Simulation
EGF
Enzyme Activation
Epidermal Growth Factor - metabolism
GEPASI
MAP Kinase Signaling System - physiology
MAPK
Mitogen-Activated Protein Kinases - metabolism
Models, Biological
PC12
PC12 Cells
Rats
Receptor tyrosine kinase (RTK)
Receptor, Epidermal Growth Factor - metabolism
Simulation
Software
Time Factors
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Summary:Abstract Computer simulations and mathematical modeling of biological processes are becoming increasingly popular, and yet the complexity of the biochemical systems or the differences between experimental setups make it very difficult to establish a standard formula for these modeling projects. Before we can start using computer-based models for predictions or targeted experiment designs, it is very important to establish a reliable model on which those predictions can be based and experimentally tested. Here we attempt to present a computer model for the mitogen-activated protein kinase (MAPK) signaling cascade which is consistent with previously published experimental results. In this study we have focused our attention to a generic MAPK ERK (extracellular signal-regulated kinase) pathway activated by epidermal growth factor (EGF) in an attempt to understand how receptors may achieve different activation kinetics of the MAPK signaling. We successfully show that the level of receptor expression is one key determinant in this regulation, and that the binding affinity of the active receptor to adaptor proteins can have a small but albeit direct effect on the downstream activation.
ISSN:1079-9893
1532-4281
DOI:10.1081/RRS-120025203