Glycosyl phenylthiosulfonates (glyco-PTS): novel reagents for glycoprotein synthesis

Controlled site-selective glycosylation can be achieved by combining site-directed cysteine mutagenesis with chemical modification of the introduced thiol; a new class of more efficient chemoselective reagents, glycosyl phenylthiosulfonates, allow rapid glycosylations of representative simple thiols...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2003-11, Vol.1 (21), p.3642
Main Authors: Gamblin, David P, Garnier, Philippe, Ward, Sarah J, Oldham, Neil J, Fairbanks, Antony J, Davis, Benjamin G
Format: Article
Language:English
Subjects:
Glycoproteins - chemical synthesis
Indicators and Reagents - chemistry
Molecular Structure
Spectrometry, Mass, Electrospray Ionization
Thiosulfonic Acids - chemistry
Online Access:Get full text
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Summary:Controlled site-selective glycosylation can be achieved by combining site-directed cysteine mutagenesis with chemical modification of the introduced thiol; a new class of more efficient chemoselective reagents, glycosyl phenylthiosulfonates, allow rapid glycosylations of representative simple thiols, peptides and proteins.
ISSN:1477-0520
DOI:10.1039/b306990g