Glycosyl phenylthiosulfonates (glyco-PTS): novel reagents for glycoprotein synthesis

Controlled site-selective glycosylation can be achieved by combining site-directed cysteine mutagenesis with chemical modification of the introduced thiol; a new class of more efficient chemoselective reagents, glycosyl phenylthiosulfonates, allow rapid glycosylations of representative simple thiols...

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Published in:Organic & biomolecular chemistry 2003-11, Vol.1 (21), p.3642
Main Authors: Gamblin, David P, Garnier, Philippe, Ward, Sarah J, Oldham, Neil J, Fairbanks, Antony J, Davis, Benjamin G
Format: Article
Language:English
Subjects:
Glycoproteins - chemical synthesis
Indicators and Reagents - chemistry
Molecular Structure
Spectrometry, Mass, Electrospray Ionization
Thiosulfonic Acids - chemistry
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container_issue 21
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container_title Organic & biomolecular chemistry
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creator Gamblin, David P
Garnier, Philippe
Ward, Sarah J
Oldham, Neil J
Fairbanks, Antony J
Davis, Benjamin G
description Controlled site-selective glycosylation can be achieved by combining site-directed cysteine mutagenesis with chemical modification of the introduced thiol; a new class of more efficient chemoselective reagents, glycosyl phenylthiosulfonates, allow rapid glycosylations of representative simple thiols, peptides and proteins.
doi_str_mv 10.1039/b306990g
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source Royal Society of Chemistry: Jisc Collections: Journals Archive 1841-2007 (2019-2023)
subjects Glycoproteins - chemical synthesis
Indicators and Reagents - chemistry
Molecular Structure
Spectrometry, Mass, Electrospray Ionization
Thiosulfonic Acids - chemistry
title Glycosyl phenylthiosulfonates (glyco-PTS): novel reagents for glycoprotein synthesis
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