Successful treatment of recalcitrant psoriasis with a combination of infliximab and hydroxyurea

We report the use of a combination of the tumour necrosis factor (TNF ) inhibitor infliximab and hydroxyurea to achieve control of disabling psoriasis and psoriatic arthritis. Our patient had psoriasis that proved resistant to conventional therapy including vitamin D analogues, topical steroids, dit...

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Bibliographic Details
Published in:The Journal of dermatological treatment 2003-12, Vol.14 (4), p.226-228
Main Authors: Gach, J E, Berth-Jones, J
Format: Article
Language:English
Subjects:
Administration, Oral
Antibodies, Monoclonal - therapeutic use
Biological and medical sciences
Dose-Response Relationship, Drug
Drug Administration Schedule
Drug Therapy, Combination
Female
Follow-Up Studies
Humans
Hydroxyurea
Hydroxyurea - therapeutic use
Infliximab
Infusions, Intravenous
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Psoriasis - diagnosis
Psoriasis - drug therapy
Recalcitrant psoriasis
Salvage Therapy
Severity of Illness Index
Skin, nail, hair, dermoskeleton
Treatment Outcome
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Summary:We report the use of a combination of the tumour necrosis factor (TNF ) inhibitor infliximab and hydroxyurea to achieve control of disabling psoriasis and psoriatic arthritis. Our patient had psoriasis that proved resistant to conventional therapy including vitamin D analogues, topical steroids, dithranol, crude coal tar, narrow band UVB, bath PUVA and acitretin. She subsequently responded to hydroxyurea 1 g daily combined with infliximab infusions repeated at three monthly intervals which led to satisfactory control of her psoriasis and psoriatic arthritis. She has not reported any side-effects from this treatment regimen and her full blood count has remained normal.
ISSN:0954-6634
1471-1753
DOI:10.1080/09546630310015386