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Cell attachment and biocompatibility of polytetrafluoroethylene (PTFE) treated with glow-discharge plasma of mixed ammonia and oxygen

The plasma generated from a gas mixture of NH 3 plus O 2 (NH 3 + O 2 ) has been used to impart unique chemical and biological characteristics to polytetrafluoroethylene (PTFE). PTFE treated with NH 3 + O 2 plasma was physiochemically distinct from surfaces treated with plasma of either NH 3 or O 2 a...

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Bibliographic Details
Published in:Journal of biomaterials science. Polymer ed. 2003-01, Vol.14 (9), p.917-935
Main Authors: Chen, Meng, Zamora, Paul O., Som, Prantika, Peña, Louis A., Osaki, Shigemasa
Format: Article
Language:English
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Summary:The plasma generated from a gas mixture of NH 3 plus O 2 (NH 3 + O 2 ) has been used to impart unique chemical and biological characteristics to polytetrafluoroethylene (PTFE). PTFE treated with NH 3 + O 2 plasma was physiochemically distinct from surfaces treated with plasma of either NH 3 or O 2 alone, as determined by electron spectroscopy for chemical analysis (ESCA). The contact angle analysis revealed that the PTFE surfaces became less hydrophobic after plasma treatments. ESCA results indicate the presence of oxygen-containing groups and nitrogen-containing groups at the plasma-treated surfaces. PTFE treated with NH 3 + O 2 plasma resisted the attachment of platelets and leukocytes in a manner similar to untreated PTFE; however, the attachment of bovine aorta endothelial cells was substantially increased. Once attached, these cells grew to confluency. The increased endothelial cell attachment was higher than that observed following plasma treatment with each gas used separately, which could be attributed to the considerable amount of CF(OR) 2 -CF 2 formed on the NH 3 + O 2 plasma-treated PTFE surface. At 14 days after subcutaneous implantation in rats, the PTFE wafers treated with NH 3 + O 2 plasma demonstrated less encapsulation and lower levels of inflammatory cells compared to controls. Collectively, the results suggest that NH3 + O2 plasma treatment imparts a unique character to PTFE and could be useful in certain in vivo applications.
ISSN:0920-5063
1568-5624
DOI:10.1163/156856203322381410