Reduced Muscle Selectivity During Individuated Finger Movements in Humans After Damage to the Motor Cortex or Corticospinal Tract

• Published in: Journal of neurophysiology 2004-04, Vol.91 (4), p.1722-1733
• Main Authors: Lang, Catherine E, Schieber, Marc H
• Format: Article
• Language: English
• Subjects: Adult; Aged; Biomechanical Phenomena - methods; Brain Mapping; Electric Stimulation - methods; Electromyography - methods; Evoked Potentials, Motor - radiation effects; Female; Fingers - physiopathology; Functional Laterality - physiology; Humans; Magnetic Resonance Imaging - methods; Male; Middle Aged; Motor Cortex - injuries; Motor Cortex - physiopathology; Movement - physiology; Muscle Contraction - physiology; Muscle, Skeletal - physiopathology; Paresis - physiopathology; Psychomotor Performance - physiology; Pyramidal Tracts - physiopathology
• ISSN: 0022-3077; 1522-1598
• DOI: 10.1152/jn.00805.2003

1 Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642 2 Department of Neurobiology and Anatomy, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642 3 Department of Physical Medicine and Rehabilitation, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642 4 Brain Injury Rehabilitation Program, St. Mary's Hospital, Rochester, New York 14642 Submitted 18 August 2003; accepted in final form 2 December 2003 We investigated how damage to the motor cortex or corticospinal tract affects the selective activation of finger muscles in humans. We hypothesized that damage relatively restricted to the motor cortex or corticospinal tract would result in unselective muscle activations during an individuated finger movement task. People with pure motor hemiparesis attributed to ischemic cerebrovascular accident were tested. Pure motor hemiparetic and control subjects were studied making flexion/extension and then abduction/adduction finger movements. During the abduction/adduction movements, we recorded muscle activity from 3 intrinsic finger muscles: the abductor pollicis brevis, the first dorsal interosseus, and the abductor digit quinti. Each of these muscles acts as an agonist for only one of the abduction/adduction movements and might therefore be expected to be active in a highly selective manner. Motor cortex or corticospinal tract damage in people with pure motor hemiparesis reduced the selectivity of finger muscle activation during individuated abduction/adduction finger movements, resulting in reduced independence of these movements. Abduction/adduction movements showed a nonsignificant trend toward being less independent than flexion/extension movements in the affected hands of hemiparetic subjects. These changes in the selectivity of muscle activation and the consequent decrease in individuation of movement were correlated with decreased hand function. Our findings imply that, in humans, spared cerebral motor areas and descending pathways that remain might activate finger muscles, but cannot fully compensate for the highly selective control provided by the primary motor cortex and the crossed corticospinal system. Address for reprint requests and other correspondence: C. E. Lang, Washington University School of Medicine, 4444 Forest Park Blvd., Campus Box 8502, St. Louis, MO 63108.